摘要
目的 了解广东汉族人甲基四氢叶酸还原酶 (MTHFR)基因的分布特点 ,并与其它地区人群进行比较。方法 应用聚合酶链反应技术对正常人甲基四氢叶酸还原酶 (MTHFR)基因进行扩增以HinfI进行限制性酶切图谱分析。结果 广东汉族人MTHFR基因中 ,表现型T/T频率是 3% ,表现型T/C是 36 5 % ,表现型C/C是 6 0 5 %。MTHFR基因T频率是 0 196 ,基因C频率是 0 80 4。结论 广东汉族人MTHFR基因的分布与其它地区及人种有不同。
Objective:To identify the distribution feature of MTHFR gene in Hans in Guangdong province. Methods:MTHFR genes from normal individuals were amplified with PCR and their restricted enzyme digested maps analysis were done with Hinf I.Results:genotypefrequency:MTHFR *T/ *T 0 030;MTHFR *T/ *C 0 3650;MTHFR *C/ *C0 6050;MTHFR Genefrequenc:MTHFR *T 0 1960;MTHFR *C 0 8040.Conclusion:The MTHFR genes distrbution in the Hans in Guangdong province is different from those in other areas.
出处
《中国优生与遗传杂志》
2002年第4期22-23,共2页
Chinese Journal of Birth Health & Heredity
