摘要
目的:探讨肽基脯氨酰顺反异构酶Pin1与β-联蛋白(β-catenin)在结直肠癌组织中的表达及其预后关系。方法:应用免疫组化技术检测结直肠癌组织中Pin1、β-catenin蛋白表达水平,分析其相互关系及其预后价值。所有统计分析采用SPSS11.5软件包完成。结果:①Pin1在40%(12/30)结直肠癌组织中过表达,β-catenin在60%(18/30)结直肠癌组织中异常蓄积,12例Pin1过表达中11例同时存在β-catenin异常蓄积,两者呈显著正相关(P=0.008);②统计分析提示Pin1过表达与预后有显著相关性(P<0.01),β-catenin与预后关系无显著统计学意义(P=0.092)。结论:结直肠癌组织中存在Pin1过表达、β-catenin异常蓄积,且两者正相关;Pin1与结直肠癌的预后密切相关。
Objective:To evaluate the expression of Pin1 and β-catenin in colorectal cancer.To identify whether Pin1 was a prognostic factor in colorectal cancer.Methods:The expression of Pin1 and β-catenin proteins was detected by immunohistochemistry in 30 cases of colorectal cancer tissues.The relationships between Pin1 and β-catenin expression and their prognostic factors were evaluated.Results:1.The overexpression of Pin1 and the aberrant accumulation of β-catenin in colorectal cancer were 38%(12/30) and 60%(18/30), respectively.A significant positive correlation was found between Pin1 and β-catenin(p=0.008).2.Pin1 was significantly related to the overall survival(p<0.01).Patients with negative β-catenin expression survived longer than those with aberrant expression despite no statistical significance was detected(p=0.092).Conclusion:Pin1 was overexpressed and β-catenin was aberrant accumulated in colorectal cancer in this study.There was a significant correlation between their expressions.Pin1 might be a prognostic factor in colorectal cancer.
出处
《内蒙古中医药》
2008年第12X期43-45,共3页
Inner Mongolia Journal of Traditional Chinese Medicine
