摘要
用放射免疫分析法分别测定了链脲佐菌素(Streptozotocin,STZ)所致的糖尿病大鼠模型在2、4、6周时的下丘脑、垂体、胰腺及血浆β-内啡肽样免疫活性物质(immunoreactive β-endorphin,ir-β-EP),并同时测定了痛阈。结果发现在糖尿病大鼠模型建立4周时,以上组织及血浆的ir-β-EP开始下降,且随病程的进展而继续下降,同时伴有痛阈的降低,与对照组比较有显著差别(P<0.01),提示糖尿病大鼠组织β-内啡肽含量降低的程度与病程和痛阈有关。
Immunoreactive beta-endorphin was measured by radioimmunoassay (RIA) in the pituitary, hypothalamus, pancreas and plasma of female diabetic rats induced by streptozotocin. In addition, pain threshold was determined. The results showed that the concentrations of beta-endorphin in pituitary, hypothalamus, pancreas and plasma began to decrease on the first month after being made diabetic. Then, the levels of beta-endorphin continued to decrease significantly as the course progressed, especially in pancreas and plasma. Diabetic rats consistently showed a decreased pain threshold after 4 weeks. These results suggested that the decrease of beta-endorphin may be related to the course of diabetes and pain threshold.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1991年第3期156-158,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
Β-内啡肽
糖尿病
下丘脑
垂体
Immunoreactive β-endorphin Pain threshold Diabetes model
