摘要
目的探讨单侧颈内动脉重度狭窄或闭塞的急性脑梗死患者侧支循环开放与脑微出血(cerebral microbleeds,CMBs)的关系。方法选取单侧颈内动脉重度狭窄或闭塞的急性脑梗死患者136例,行数字减影血管造影检查,按侧支循环开放情况分为A组(前交通动脉开放组61例)、B组(后交通动脉开放组35例)、C组(非前、后交通动脉开放组40例)。采用3. 0 T Philips核磁共振(magnetic resonance imaging,MRI)行磁敏感加权成像(susceptibility weighted imaging,SWI)扫描并计算6个月及12个月时新增CMBs的数目。结果 6个月时,A组新增CMBs 14个,B组新增CMBs 9个,C组新增CMBs 13个,3组比较差异无统计学意义(P> 0. 05)。12个月时,A组新增CMBs 19例,B组新增CMBs 11例,C组新增CMBs 22例,A组与B组相比差异无统计学意义(P> 0. 05),A组与C组,B组与C组相差异均有统计学意义(P <0. 05)。6个月与12个月相比,C组差异有统计学意义(P <0. 05),A组或B组均无明显差异(P> 0. 05)。结论急性脑梗死单侧颈内动脉重度狭窄或闭塞的患者,侧支循环的开放,尤其是前、后交通动脉的开放,可在一定程度上减少CMBs的形成。
Objective To investigate the relationship between opening of collateral circulation and cerebral microbleeds （CMBs） in patients with acute cerebral infarction （ACI） who had severe unilateral internal carotid artery （ICA） stenosis or occlusion. Methods A total of 136 patients with ACI who had severe unilateral ICA stenosis or occlusion were selected, and digital subtraction angiography was performed. According to the opening condition of collateral circulation, the patients were divided into group A （including 61 patients with anterior communicating artery opening） and group B （including 35 patients with posterior communicating artery opening） and C group （including 40 patients without anterior or posterior communicating artery opening ）. Susceptibility weighted imaging （SWI） by 3.0 T Philips Magnetic Resonance Imaging （MRI） was calculate the number of new CMBs at 6 and 12 months. Results At 6 months, there were 14 new CMBs in group A, 9 in group B, and 13 in group C, and no significant difference was found between the three groups （P 〉0.05）. At 12 months, the number of new CMBs was 19, 11 and 22 in group A, group B, and group C, respectively, and no significant difference was noted between group A and group B （P 〉 0.05 ）. However, there were significant differences between group A and group C as well as between group B and group C （ P 〈 0.05 ）. There was a statistically significant difference in group C between the 6th and 12th months （ P 〈 0.05 ） , while no significant difference was observed in group A and group B （ P 〉 0.05 ）. Conclusion In patients with ACI who had severe unilateral ICA stenosis or occlusion, the opening of the collateral circulation, especially the opening of the anterior and posterior communicating arteries, can reduce the formation of CMBs to a certain extent.
作者
张军
赵娴
曹献国
宋哲
刘惠钦
李献军
ZHANG Jun;ZHAO Xian;CAO Xianguo(Department of Neurology,The First Hospital of Shijiazhuang City,Hebei,Shijiazhuang 050011,China)
出处
《河北医药》
CAS
2018年第24期3777-3780,共4页
Hebei Medical Journal
基金
石家庄市科学技术研究与发展指导计划课题(编号:141462463)
关键词
急性脑梗死
脑微出血
侧支循环
血管造影
颈内动脉狭窄
acute cerebral infarction
cerebral microbleeds
lateral branch circulation
digital subtractionangiography
carotid artery stenosis
