摘要
目的：优化十一方巴布剂的基质处方。方法：在单因素试验的基础上，以巴布剂的综合感官评分和初黏力评分的总评归一值（0D）为综合评价指标，采用星点设计效应面法优化十一方巴布剂的基质处方。结果：十一方巴布剂的最佳基质处方为CMCNa1·6g，PVPK3010·0g，PEG4001．0g，高岭土13．0g，甘油15．0g，十一方药酒20ml。结论：星点设计效应面法优化得到的十一方巴布剂基质配方合理，制备得到的巴布剂外观性状良好，黏附力适中。
Objective： To optimize the matrix recipe of Shiyifang eataplasm. Methods： Taking of composite score of appearance description and initial bonding strength as composite index, based single factor tests, central composite design matrix recipe of Shiyifang eataplasm. Results： response surface methodology was used to optimize The optimal ratio of the matrix is as follows： CMC OD on the Na 1.60 g, PVP K30 10.0 g, PEG400 1.0 g, kaoline13.0 g, glycerin15.0 g, shiyifang vinum 20 ml. Conclusion： The matrix recipe of Shiyifang cataplasm, optimizing by central composite design-response surface methodology, is reasonable. The eataplasm has the good appearance and moderate adhesion.
作者
施显怡
王志萍
黎芳
廖乃英
王孝勋
蔡雪梅
陈晓艺
黄杰连
Shi Xianyi;Wang Zhiping;Li Fang;Liao Naiying;Cai Xuemei;Chen Xiaoyi;Huang Jielian(Guangxi University of Chinese Medicine,Guangxi,Nanning,530200;Key Laboratory of Common Technology of Traditional Chinese Medicine Preparation,Nanning,530001)
出处
《壮瑶药研究季刊》
2018年第1期111-119,141,共9页
Research of Zhuang and Yao Ethnic Medicine
基金
广西高校科技创新能力提升工程专项项目(70-ZJGX2016001)
自治区级硕士研究生科研创新项目(YCSW2017170)
校级项目(P2016001)
壮瑶药协同创新中心项目(桂教科研[2013] 20号)
广西重点学科壮药学(桂教科研[2013]16号)
广西八桂学者中药创新理论与药效研究
广西壮瑶药重点实验室(桂科基字[2014]32号)
关键词
十一方巴布剂
星点设计
效应面法
基质处方
shiyifang cataplasm
central composite design
response surface methodology
matrixrecipe
