摘要
目的探讨PCOS患者血清AMH水平与其内分泌及IVF-ET/ICSI临床结局关系,并评估AMH与这些指标的相关性。方法回顾性分析111例PCOS患者的一般情况及IVF-ET/ICSI临床结局。根据AMH水平将其分为A(AMH≤5.66),B(5.66<AMH≤7.94),C(7.94<AMH≤11.87),D(11.87<AMH)四组,并比较四组间的内分泌及IVF-ET/ICSI临床结局相关指标的差异性。结果各组在年龄、BMI、bT、bLH、临床妊娠率、活产率无上无统计学差异(P>0.05)。但在较高AMH水平下,bFSH、AFC、Gn量、HCG日E2水平、获卵数、优胚数存在差异(P<0.05)。进行相关分析时,发现bT、bE2、临床妊娠率、活产率无相关关系(P>0.05),而AMH与年龄、BMI、FSH、Gn量成负相关(P<0.05),与LH、HCG日E2、AFC、获卵数成正相关(P<0.05)。结论血清AMH水平对PCOS患者IVF-ET/ICSI临床结局无直接相关性。
Objective： Investigating the relationship between serum AMH levels and clinical outcomes of endocrine parameters and IVF-ET/ICSI in patients with PCOS, and evaluating the association of AMH with these indicators. Methods： A retrospective analysis of 111 cases of PCOS patients and IVF-ET/ICSI chnical outcomes. According to AMH levels, the study divide it into four groups： A （AMH≤5.66） , B （5.66〈AMH ≤7.94） , C （7.94〈AMH≤ll.87） , and D （ll.87〈AMH） , and compare the endocrine parameters and IVF-ET/ICSI clinical outcomes between the four groups. Results： There was no significant difference in age, BMI, bT, bLH, clinical pregnancy rate, and live birth rate among the groups （P〉0.05） . However, at higher AMH levels, there were differences in bFSH, AFC, Gn levels, HCG day Ez levels, number of retrieved eggs, and number of embryos （P〈0.05） . When correlation analysis was performed, there was no correlation among bT, bE2, clinical pregnancy rate, and live birth rate （P〉0.05） , but AMH was negatively correlated with age, BMI, FSH, and Gn （P〈0.05） , and positively correlated with LH, HCG E2, AFC, and the number of retrieved eggs （P〈0.05） . Conclusion： Serum AMH levels have no direct correlation with the IVF-ET/ICSI clinical outcomes in patients with polycystic ovary syndrome.
作者
殷露
穆杨
黄小烜
尹太郎
胡雪
杨菁
YIN Lu;MU Yang;HUANG Xiao-yuan;YIN Tai-lang;HU Xue;YANG Jing(Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《中国优生与遗传杂志》
2018年第11期116-119,82,共5页
Chinese Journal of Birth Health & Heredity
