摘要
Wnt信号通路分为经典Wnt信号通路和非经典Wnt信号通路,而非经典Wnt信号通路又可分为Wnt/Ca^(2+)信号通路、Wnt/PCP信号通路和Wnt/PI3K信号通路。经典Wnt信号通路的恰当激活可有效抑制Notch信号通路,促进成肌分化和肌管融合。但经典Wnt信号通路过早或持续性激活,可通过调节多种细胞因子的表达,加重损伤骨骼肌纤维化,损害骨骼肌再生。而Wnt7a通过多条非经典Wnt信号通路刺激肌卫星细胞扩增、迁移,促进骨骼肌损伤修复,并能激活Akt/mTOR信号通路而诱导肌纤维肥大。
Writ signaling pathway is divided into canonical and non-canonical Wnt signalling. The non- canonical Wnt signaling is composed of Wnt/Ca2＋ signalling, Wnt/PCP signalling and Wnt/PI3K signalling. The appropriate activation of canonical Writ signaling pathway can inhibit the Notch signaling pathway, pro- mote myogenic differentiation and myotube formation. However, the premature or persistent activation of the canonical Wnt signaling can aggravate fibrosis and damage skeletal muscle regeneration by regulating the ex- pression of cytokines, in addition, Wnt7a stimulates muscle satellite cell proliferation and migration through a number of non-canonical Wnt signaling pathways, promotes skeletal muscle repair, and activates Akt/mTOR signaling pathway to induce skeletal muscle hypertrophy.
作者
刘晓光
陈佩杰
肖卫华
LIU Xiaoguang;CHEN peijie;XIAO Weihua＊(School of Kinesiology,Shanghai University of Sport,Shanghai 200438,China)
出处
《生命的化学》
CAS
CSCD
2018年第5期724-730,共7页
Chemistry of Life
基金
国家自然科学基金项目(31300975
31271273)
上海市自然科学基金项目(18ZR1437100)
上海市人类运动能力开发与保障重点实验室(11DZ2261100)资助项目
关键词
WNT信号通路
骨骼肌
损伤
修复
Wnt signaling pathway
skeletal muscle
injury
repair
