摘要
目的合成一种新型氯代N-哌啶二苯并环庚烯类杀鼠剂。方法以5-哌啶基-10,11-二氢二苯并[a,d]环庚烯为母体合成2-氯-N-哌啶-10,11-二氢二苯并环庚烯,测试母体和该杀鼠剂的半致死量。在沈阳某地进行现场灭杀试验。结果生化试验表明,5-哌啶基-10,11-二氢二苯并[a,d]环庚烯对褐家鼠LD50为7.99～9.05mg/kg,对小白鼠LD50为859.41～967.12 mg/kg,2-氯-N-哌啶-10,11-二氢二苯并环庚烯对褐家鼠LD50为5.40～6.13 mg/kg,对小白鼠LD50为735.33～819.45 mg/kg。合成产物的现场灭杀试验校正灭鼠率约为84.99%。结论所合成的2-氯-N-哌啶-10,11-二氢二苯并环庚烯毒性有所加强,选择性更好,个体差异性更小,是一种更加优良的高选择性杀鼠剂。
Objective To synthesize a new type of chlorinated N-piperidine dibenzoheptene rodenticides. Methods In this study,2-chloro-5-piperidinyl-10,11-dihydrodibenzo [a,d]cycloheptene was synthesized from 5-piperidinyl-10,11-dihydrodibenzo [a,d]cycloheptene,the matrix,to test the lethal dose of the parent and the rodenticide. The site extermination test was conducted in a certain place in Shenyang. Results According to biochemical experimental results,the semi-lethal dose of dibenzosuberone to rattus norvegicus was about 7. 99 ～ 9. 05 mg/kg,while to mus musculus was about 859. 41 ～967. 12 mg/kg. The semi-lethal dose of 2-chloro-5-piperidinyl-10,11-dihydrodibenzo[a,d]cycloheptene to rattus norvegicus was about 5. 40 ～ 6. 13 mg/kg,while to mus musculus was about 735. 33 ～ 819. 45 mg/kg. The corrected rodent rate of new rodenticide＇s on-site extermination test was about 84. 99%. Conclusion The synthesized 2-chloro-5-piperidinyl-10,11-dihydrodibenzo[a,d]cycloheptene has enhanced toxicity,better selectivity and less individual differences,and is a more excellent and highly selective rodenticide.
作者
宁淑钧
陈锋
仇勃文
NING Shujun;CHEN Feng;QIU Bowen(College of Science,Northeastern University,Liaoning Shenyang 110819,China)
出处
《医学动物防制》
2018年第12期1129-1132,共4页
Journal of Medical Pest Control
基金
第十一批大学生创新创业训练计划(20171014)
关键词
选择性
杀鼠剂
二苯并环庚烯
氯代
褐家鼠
Selectivity
Rodenticides
Dibenzocyctoheptene
Chloride
Rattus norvegicus
