摘要
目的:分析碳酸镧所致药品不良反应(ADR)的发生情况,为临床安全用药提供参考。方法:收集国内外公开报道的碳酸镧ADR的文献资料,按患者年龄、性别、原患疾病,ADR发生时间、累及器官及临床表现、转归等进行整理分析。结果:共收集到碳酸镧ADR16例,男9例(56%),女7例(44%),年龄61~70岁患者10例(62. 5%),发生时间尤其应注意用药后4年以上(33. 33%)。累及器官主要有胃肠系统,临床表现有恶心、呕吐、腹痛、麻痹性肠梗阻、腹膜炎等。1例(6. 25%)患者死亡。结论:碳酸镧所致ADR需引起临床高度重视,注意患者用药教育及随访,避免严重不良反应的发生。
Objective： To study the effects of lanthanum carbonate（ LC） adverse drug reactions（ ADR） occurred,and provide reference for clinical rational and safe medication. Methods：LC ADRs domestically and internationally reported were collected and analysed in respects of age,gender,the original illness,ADR occurrence time,clininal manifestations and the results. Results：After retrieval,there were 16 cases of LC ADRs,including 9 men（56%） and 7 women（44%）. Patients over the age of 61-70 years showed the higher incidence（n = 10,62. 5%）. The occurrence time should be with particular attention within 4 years after administration（33. 33%）. Main clinical manifestations were gastrointestinal system. The main clinical manifestations of LC drug reactions were nausea,emesis,stomachache,paralytic ileus and peritonitis. 1 patient（6. 25%） died. Conclusion：LC-induced ADR should be emphasized,and pay attentions to patient medication education to avoid serious adverse reactions.
作者
李璐璐
张耕
Li Lulu;Zhang Geng(Department of Pharmacy,Wuhan No.1 Hospital,Wuhan 430022,China)
出处
《药物流行病学杂志》
CAS
2018年第11期769-773,共5页
Chinese Journal of Pharmacoepidemiology
关键词
碳酸镧
药品不良反应
文献计量学
Lanthanum carbonate
Adverse drug reactions
Bibliometrics
