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米非司酮联合米索前列醇和人工流产治疗稽留流产的优劣差异 被引量:7

Mifepristone combined with misoprostol and artificial abortion in the treatment of missed abortion
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摘要 目的探究米非司酮联合米索前列醇和人工流产治疗稽留流产的优劣差异。方法回顾性分析2016年12月~2017年12月间收治的稽留流产患者40例,根据治疗方式进行分组。对照组患者口服戊酸雌二醇后行人工流产钳刮术治疗,观察组患者采用米非司酮联合米索前列醇药物后行清宫术治疗,对比两组患者治疗效果及不良反应。结果观察组完全流产率80.00%显著高于对照组45.00%,差异无统计学意义(P> 0.05);观察组患者子宫开始收缩时间、服药后排胎时间、排胎2h内出血量优于对照组,差异有统计学意义(P <0.05);观察组不完全流产患者的术中出血量、手术时间、术后阴道出血时间显著优于对照组,差异有统计学意义(P <0.05);两组患者均未出现严重不良反应,且停药后自动消失。结论采用米非司酮联合米索前列醇治疗稽留流产效果显著,且完全流产率高,手术时间、排胎时间短,出血量少,价值显著。 Objective To explore the difference between mifepristone combined with misoprostol and artificial abortion in the treatment of missed abortion. Methods Retrospective analysis of 40 patients with missed abortion admitted between December 2016 and December 2017,the patients were divided into groups according to the treatment methods.Patients in the control group were treated with estradiol valerate for artificial abortion,patients in the observation group were treated with mifepristone combined with misoprostol for uterine curettage,the treatment effects and adverse reactions were compared between the two groups of patients. Results The complete abortion rate of 80.00% in the observation group was significantly higher than that of 45.00% in the control group,the difference was not statistically signifieant (P 〉 0.05);In the observation group,the time of uterus contraction,the time of queuing after taking the drug,and the amount of bleeding within 2 hours of the fetus were better than the control group,the difference was statistically significant (P 〈 0.05);The intraoperative blood loss,operation time,and postoperative vaginal bleeding time were significantly better in the observation group than in the control group,the difference was statistically significant (P 〈 0.05);There were no serious adverse reactions in the two groups and disappeared automatically after drug withdrawal. Conclusion The use of mifepristone eombined with misoprostol in the treatment of missed abortion is signifieant,and the complete abortion rate is high,the operation time,the time of the fetus is short,the amount of bleeding is small,and the value is significant.
作者 邹晴鹏 ZOU Qingpeng(Department of Obstetrics and Gynecology,Chenghai District Maternal and Child Health Care Hospital,Shantou 515800,China)
出处 《中国医药科学》 2018年第20期124-126,146,共4页 China Medicine And Pharmacy
关键词 米非司酮 米索前列醇 人工流产 稽留流产 优劣差异 Mifepristone Misoprostol Artificial abortion Missed abortion Differenees in strengths and weaknesses
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