摘要
目的探讨18F-FDG PET/CT在宫颈鳞状细胞癌治疗后血清鳞状细胞癌抗原(SCC-Ag)升高患者中的应用价值。方法回顾性分析52例宫颈鳞癌手术和(或)放、化疗后血清SCC-Ag升高(>1.5μg/L)患者,18F-FDG PET/CT全身扫描查找有无复发和(或)转移灶。以病理学和(或)随诊结果为诊断标准,评价PET/CT对宫颈鳞癌复发和(或)转移的诊断效能。随访时间6～12个月。结果 PET/CT发现异常代谢增高灶者44例,阴性表现者8例。42例患者经组织病理或临床随诊证实复发和(或)转移,PET/CT诊断宫颈鳞癌术后复发和(或)转移假阳性3例、假阴性1例,PET/CT诊断宫颈鳞癌复发和(或)转移的敏感度为97.6%(41/42),特异度为70.0%(7/10),阳性预测值为93.2%(41/44),阴性预测值为87.5%(7/8),准确度为92.3%(48/52)。PET/CT显像诊断结果与组织病理(和)或临床随诊结果具有高度一致性(Kappa值=0.732)。结论18F-FDG PET/CT是宫颈鳞癌治疗后SCC-Ag升高患者复发和(或)转移的有效诊断方法,具有重要的临床应用价值。
Objective To investigate the diagnostic value of ^18F- fluorodeoxyglucose （^18F-FDG） positron emission tomography/computed tomography （PET/CT） in uterine cervix squamous cell cancer patients with squamous cell carcinoma antigen（SCC-Ag）elevation after treatment. Methods Data of 52 cervical squamous cancer patients with elevated SCC-Ag （〉1.5 μg/L） after surgery and/or radiotherapy and chemotherapy were retrospectively analyzed. ^18F-FDG PET/CT was used for full body scanning to show the recurrence and/or metastasis in patients. The diagnostic efficiency of PET/CT in the recurrence and/or metastasis of cervical squamous cell carcinoma was evaluated according to pathological and （or） follow-up results. The follow-up period was 6 to 12 months. Results There were positive ^18F-FDG PET/CT findings in 44 patients and negative ^18F-FDG PET/CT findings in 8 patients. There were 3 false-positive and 1 false-negative cases. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of diagnostic efficiency of PET/CT were 97.6% （41/42）, 70.0% （7/10）, 93.2% （41/44）, 87.5%（7/8） and 92.3%（48/52） respectively. The diagnostic results of ^18F-FDG PET/CT are highly consistent with histopathological and （or） clinical follow-up results （Kappa value=0.732, P〈0.01）. Conclusion ^18F-FDG PET/CT can reliably identify and accurately detect the recurrence and （or） metastasis of cervical squamous cancer in patients with elevated SCC-Ag after treatment, which has important clinical application value.
作者
史文杰
王小杰
毛媛媛
宋申
SHI Wen-jie;WANG Xiao-jie;MAO Yuan-yuan;SONG Shen(PET/CT Center,People＇s Liberation Army NO.254 Hospital,Tianjin 300142,China)
出处
《天津医药》
CAS
北大核心
2018年第11期1209-1212,共4页
Tianjin Medical Journal
关键词
氟脱氧葡萄糖F18
正电子发射断层显像术
体层摄影术
X线计算机
宫颈肿瘤
癌
鳞状细胞
复发
肿瘤转移
鳞状细胞癌抗原
fluorodeoxyglucose F18
positron-emission tomography
tomography
X-ray computed
uterine cervical neoplasms
carcinoma
squamous cell
recurrence
neoplasm metastasis
squamous cell carcinoma antigen
