摘要
目的探讨^18F—FDGPET／CT显像在诊断子宫内膜癌术后复发、转移中的临床价值。方法回顾性分析2004年10月至2014年2月在南方医科大学南方医院PET中心进行检查的62例子宫内膜癌术后患者的显像结果，以病理和临床随访结果为确诊标准，评价PET／CT对子宫内膜癌术后复发、转移灶的诊断效能。结果62例患者中经病理及临床随访证实为子宫内膜癌术后复发、转移者28例，第二原发癌（无复发、转移）9例。PET／CT显像有3例假阳性。2例假阴性。PET／CT对子宫内膜癌术后复发、转移诊断的灵敏度、特异性及准确性分别为93．3％（28／30）、90．6％（29／32）、91．9％（57／62）；PET／CT显像对阴道残端复发、淋巴结转移及远处转移诊断的灵敏度、特异性分别为9／10和98．1％（51／52），95．7％（22／23）和92．3％（36／39），15／18和95．5％（42／44）。结论PET／CT对监测子宫内膜癌术后复发、转移具有较高的灵敏度和特异性，并能及时检出第二原发癌。
Objective To evaluate the clinical value of ^18F-FDG PET/CT in the diagnosis of recurrent and metastatic endometrial cancer. Methods A total of 62 patients with endometrial cancer from October 2004 to February 2014 were retrospectively analyzed. The diagnostic efficiency of ^18F-FDG PET/CT for the detection of recurrent and metastatic endometrial cancer was evaluated based on the results of pathological biopsy or clinical follow-up. Results There were 28 endometrial cancer cases with recurrence and metastasis, 9 cases with a second primary cancer and without recurrence and metastasis of endometrial carcinoma. PET/CT imaging had false positive findings in 3 cases, false negative findings in 2 cases. The overall sensitivity, specificity and accuracy of PET/CT for detection of recurrence and metastatic endometrial carcinoma were 93.3% （28/30）, 90.6% （ 29/32）, 91.9% （ 57/62）, respectively. The sensitivity and specificity of PET/CT for the diagnosis of vaginal stump recurrence, lymph node metastasis and distant metastasis were 9/10 and 98.1% （51/52）, 95.7%（22/23） and 92.3%（36/39）, 15/18 and 95.5%（42/44）, respectively. Conclusion ^18F- FDG PET/CT is a useful diagnostic tool for the detection of recurrent and metastatic endometrial cancer and a second primary cancer.
出处
《中华核医学与分子影像杂志》
CAS
北大核心
2016年第1期39-43,共5页
Chinese Journal of Nuclear Medicine and Molecular Imaging
