摘要
目的探索SiewertⅡ/Ⅲ型胃食管结合部腺癌(AEG)淋巴结转移的影响因素及其对患者预后的影响。方法回顾性分析2010年1月至2013年1月期间十堰市中医医院收治的49例SiewertⅡ/Ⅲ型AEG患者的临床病理学资料。AEG淋巴结转移影响因素的单因素和多因素分析分别采用成组χ2检验和非条件logistic回归模型;淋巴结转移对患者预后的影响分析采用log-rank检验。结果多因素非条件logistic回归分析结果显示,肿瘤直径(P=0.008)、浸润深度(P=0.019)、脉管癌栓(P=0.020)和分化程度(P=0.017)均是淋巴结转移的影响因素。无淋巴结转移的SiewertⅡ/Ⅲ型AGE患者的生存情况优于淋巴结转移者(P=0.005)。结论肿瘤直径、侵犯深度、分化程度和脉管癌栓是影响SiewertⅡ/Ⅲ型AEG患者淋巴结转移的独立危险因素,且淋巴结转移与患者的不良预后有关。
Objective To explore the influencing factors of lymph node metastasis of Siewert Ⅱ/Ⅲ gastroesophageal junction adenocarcinoma （AEG） and its influence on prognosis of this kind of patients. Methods The clinical and pathological data of 49 patients with SiewertⅡ/ⅢAEG who admitted to Shiyan Hospital of Traditional Chinese from January 2010 to January 2013 were retrospectively analyzed. Univariate and multivariate analyses of factors affecting lymph node metastasis of AEG were performed by using a chi-square test and an unconditional logistic regression model; the effect of lymph node metastasis on the prognosis of patients with Siewert Ⅱ/Ⅲ AEG was performed by log-rank test. Results Multivariate unconditional logistic regression analysis showed that, tumor diameter （P=O.O08）, depth of invasion （P=0.019）, vascular tumor thrombus （P=0.020）, and degree of differentiation （P=0.017） were all influencing factors of lymph node metastasis. Patients with Siewert Ⅱ/Ⅲ AGE without lymph node metastasis had better survival than those with lymph node metastasis （P=0.005）. Conclusion Tumor diameter, depth of invasion, degree of differentiation, and vascular tumor thrombus are independent risk factors for lymph node metastasis in patients with Siewert Ⅱ/Ⅲ AEG, and lymph node metastasis is associated with poor prognosis.
作者
高军
李富良
何旭
GAO Jun, LI Fuliang, HE Xu(Department of General Surgery, Shiyan Hospital of Traditional Chinese, Shiyan, Hubei 442012, P. R. China)
出处
《中国普外基础与临床杂志》
CAS
2018年第11期1327-1331,共5页
Chinese Journal of Bases and Clinics In General Surgery
关键词
胃食管结合部腺癌
淋巴结转移
预后
adenocarcinoma of gastroesophageal junction
lymph node metastasis
prognosis
