摘要
为研究制备方法对药物涂层的影响,分别采用超声喷涂法和喷墨打印法在药物洗脱支架表面制备以聚乳酸(PLA)为缓释物的雷帕霉素载药涂层。首先通过对PLA进行凝胶渗透色谱实验、差示扫描量热实验和拉伸试验,说明其物理化学性质能够用做药物支架的涂层材料。傅立叶红外光谱(FT-IR)结果显示药物雷帕霉素有效分布在聚合物PLA中。然后将两种方式制得的支架在扫描电子显微镜(SEM)下观察涂层的形貌;再利用球囊扩张法分析涂层与支架基体之间的结合力;最后在PBS(pH值=7.4)介质中模拟体液测试两种支架的药物释放动力学曲线。结果表明,两种方法制备的药物涂层在表面形貌、与支架基体之间的结合力方面均存在差异,药物释放曲线表明喷墨打印法制得的药物洗脱支架的整体释放趋势更为平缓。
In order to understand the effect of preparation methods on stent coating, sirolimus loaded polylactic acid coating were prepared on the surface of stent by ultrasonic spraying method and the ink-jet printing method respectively. The gel permeation chromatography （GPC）, differential scanning calorimetry （DSC） and strain-stress test of PLA demonstrated that the physical and chemical properties of the coating material could be used as a drug coating. Fourier transform infrared spectrometry （FT-IR） showed that sirolimus was effectively distributed in PLA. The two stents were used to observe the appearance of the coating under scanning electron microscope （SEM）. Furthermore, the bonding strength between the coating and the stent was analyzed by Balloon dilatation and the drug release kinetics curves of the two stents were tested in simulated humoral by PBS （pH=7.4）. The results demonstrate that there are some differences in surface morphology and bonding strength. The drug release curve indicates that the overall release trend of drug-eluting stents obtained by inkjet printing is more stable.
作者
束宇婷
常兆华
叶萍
张劼
SHU Yuting;CHANG Zhaohua;YE Ping;ZHANG Jie(School of Medical Instrument and Food Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;Shanghai Microport Medical Device Co.Ltd.,Shanghai 201203,China)
出处
《功能材料》
EI
CAS
CSCD
北大核心
2018年第11期11205-11208,共4页
Journal of Functional Materials
基金
上海市科学技术委员会科研计划资助项目(16DZ1930400)
关键词
聚乳酸
雷帕霉素
载药涂层
超声喷涂法
喷墨打印法
polylactic acid
sirolimus
drug-coating
ultrasonic spraying method
ink-jet printing method
