摘要
角质形成细胞是皮肤表皮的主要构成细胞，也是砷作用于皮肤的主要靶细胞。虽然，流行病学上已明确砷可导致掌跖过度角化及皮肤癌，但其作用机制尚不明确，也一直没有理想的动物模型。目前，砷致皮肤损伤的研究，主要以体外培养的角质形成细胞为研究对象。本文通过对相关文献进行归纳整理，从砷对角质形成细胞的促进增殖、抑制分化、氧化应激、DNA损伤、细胞凋亡、表观遗传改变及肿瘤干细胞激活7个方面作用进行综述，希望能加深对砷致皮肤损伤的认识，为地方性砷中毒的发病机制研究提供更多依据和思路。
Keratinocytes are the main constituent cells of the skin epidermis and the main target cells of arsenic act on the skin as well. Although it has been epidemiologically clarified that arsenic can cause palmoplantar hyperkeratosis and skin cancer, yet the mechanism is unclear and there＇s no ideal animal models so far. Currently, the studies of skin lesions induced by arsenic mainly focus on keratinocytes in vitro. In this paper, we summarize the related literatures and review the effects of arsenic on proliferation, differentiation, oxidative stress, DNA damage, apoptosis, epigenetic changes, and cancer stem cell activation of keratinocytes. We hope to deepen the understanding of skin lesions induced by arsenic and provide more basis and ideas for understanding the mechanism of endemic arsenicosis.
作者
李忠哲
姚金印
高琳
Li Zhongzhe;Yao Jinyin;Gao Lin(Institute for Endemic Fluorosis Control,Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Harbin Medical University,Harbin 150081,China)
出处
《中华地方病学杂志》
CAS
CSCD
北大核心
2018年第11期937-942,共6页
Chinese Journal of Endemiology
基金
国家自然科学基金（81302388）
中国博士后科学基金（2015M581485、2016T90314）
