摘要
目的探讨新生儿重症高胆红素血症的病因及危险因素,为临床诊治提供参考依据。方法选择2014年1月-2016年12月航空总医院新生儿5 523例,其中重症高胆红素血症患儿128例,采用自行设计的表格,统一收集母亲、婴儿、围生三方面的因素,采用多因素回归分析探讨影响发病的危险因素。结果 128例重症高胆红素血症患儿中,感染是最常见的发病因素,占34. 38%,其次依次为不明原因(31. 25%)、早产(12. 50%)、头颅血肿(8. 59%)、溶血(7. 03%)和窒息(6. 25%);多因素Logistics回归分析显示胎龄(<37周)、感染、母子血型不合是重症高胆红素血症发病的危险因素。结论感染、母子血型不合、早产是重症高胆红素血症发病的危险因素,临床上应积极制定防治措施,重视产前检查和产后访视,减少重症高胆红素血症的发生。
Objective To explore the causes and risk factors of severe neonatal hyperbilirubinemia （NHB） in 128 newborns. Methods 5 523 cases of newborns were enrolled from Jan 2014 to Dec 2016, among them, there were 128 newborns with severe NHB. A self-designed table was used to collect the factors related to mother, baby and perinatal, and the risk factors of the disease were analyzed by multiple regression analysis. Results The infection was the most common cause, accounting for 34. 38% , followed by unknown causes （31.25%）, preterm birth （ 12. 50% ） , cranial hematoma （8.59%） , hemolysis （7.03%） and asphyxia （6. 25% ） . Gestational age （ 〈37 w）, infection and maternal and child blood group incompatibility were the risk factors of severe hyperbilirubinemia. Conclusion The infection, maternal and child blood group incompatibility and premature birth are the risk factors of severe NHB. In clinical practice, pre- vention and treatment measures should be developed, pay more attention to prenatal examination and post natal visit could help reduce the incidence of severe hyperbilirnbinemia.
作者
王秋月
王丽
刘韬
WANG Qiu-Yue;WANG Li;LIU Tao(Department of Paediatrics,General Hospital of China Aviation,Beijing,100102,China)
出处
《中国妇幼保健》
CAS
2018年第21期4902-4904,共3页
Maternal and Child Health Care of China
基金
首都卫生发展科研专项项目(首发2016-1-2041)
