摘要
目的探讨喹硫平或阿立哌唑联合丙戊酸钠治疗双相情感障碍(BPD)抑郁发作的疗效。方法回顾性分析96例BPD抑郁发作患者临床资料,根据治疗方案不同分为阿立哌唑组与喹硫平组。阿立哌唑组应用阿立哌唑+丙戊酸钠治疗,喹硫平组应用喹硫平+丙戊酸钠治疗。在治疗前和治疗8 w后,评估患者躁狂症状[贝克拉范森躁狂量表(BRMS)]、认知功能[蒙特利尔认知功能评定量表(MoCA)]、生活质量综合评定量表74(GQOLI-74),比较两组临床疗效[汉密尔顿抑郁量表17(HAMD-17)]和不良反应发生率。结果治疗8 w后,两组临床疗效、不良反应发生率比较无显著差异(P> 0.05);两组BRMS评分均降低(P <0.05)、GQOLI-74评分均提高(P <0.05),但BRMS评分组间无显著差异(P> 0.05),GQOLI-74评分中,阿立哌唑组躯体、社会功能得分高于喹硫平组(P <0.05);阿立哌唑组MoCA评分较同组治疗前及同期喹硫平组均更高(P <0.05),而喹硫平组治疗前后无显著变化(P> 0.05)。结论喹硫平或阿立哌唑联合丙戊酸钠治疗BPD抑郁发作均疗效良好,但阿立哌唑改善患者认知功能和生活质量的效果更好。
Objective To explore the effects of quetiapine or aripiprazole combined with sodium valproate in the treatment of depressive episode of bipolar disorder （BPD）. Methods The clinical data of a total of 96 patients with depressive episode of BPD were retrospectively analyzed and were divided into an aripiprazole group and a quetiapine group according to different therapies. The aripiprazole group was treated with aripiprazole ＋ sodium valproate, and the quetiapine group with quetiapine ＋sodium valproate. Before the treatment and eight weeks after the treatment, the bipolar symptoms [beck lavansen manic seale（BRMS）], cognitive function [Montreal cognitive function rating scale （MoCA）], and the comprehensive rating scale 74 for quality- of life （GQOLI-74） in patients were evaluated. The effects [Hamilton depression scale 17 （HAMD-17）] and the incidence of adverse reactions between the two groups were compared. Results Eight weeks after the treatment, there was no significant difference in the effects and the incidence of adverse reactions between the two groups （P 〉 0.05）; the BRMS scores in the two groups decreased （P 〈 0.05）, but GQOLI-74 scores increased （P 〈 0.05）; however, there was no significant difference in BRMS scores between the two groups （P 〉 0.05）. In temps of GQOLI-74 scores, the scores of physical and social functions in the aripiprazole group were higher than those in the quetiapine group （P 〈 0.05）; the MoCA scores in the aripiprazole group were higher than those before the treatment and those in the quetiapine group during the emTesponding period （P 〈 0.05）, but there was no significant change in the MoCA scores before and after the treatment in the quetiapine group （P 〉 0.05）. Conclusion Quetiapine or aripiprazole combined with sodium valproate has good effects in the treatment of depressive episode of BPD, but aripiprazole has better effects in improving the cognitive function and quality of life in patients.
作者
李燕华
蒋婉丽
Li Yanhua;Jiang Wanli(Department of Acute Psychiatry,the Fourth People＇s Hospital of Chengdu,Chengdu,Sichuan,610036,China)
出处
《西南国防医药》
CAS
2018年第11期1010-1012,共3页
Medical Journal of National Defending Forces in Southwest China
