摘要
目的:观察疏肝利胆和胃汤联合西咪替丁治疗肝胃不和型急性胃炎患者的疗效及对血清胃泌素、胃动素及炎性因子的影响。方法:选取肝胃不和型急性胃炎患者116例作为研究对象,按照随机数字表法分为观察组和对照组各58例。2组均给予常规治疗,在此基础上对照组给予西咪替丁治疗,观察组在对照组基础上联合疏肝利胆和胃汤治疗。观察2组中医证候积分、症状缓解时间、临床疗效,检测血清胃泌素、胃动素及肿瘤坏死因子-α(TNF-α)、转化生长因子-β1 (TGF-β1)、白细胞介素-6(IL-6)水平。结果:观察组总有效率93.10%,显著高于对照组79.31%(P <0.05)。治疗前,2组中医症候积分、血清胃泌素、胃动素水平、炎性因子TNF-α、TGF-β1、IL-6水平比较,差异无统计学意义(P> 0.05)。治疗后,2组中医症候积分、血清胃泌素水平、TNF-α、TGF-β1、IL-6水平显著低于治疗前(P <0.05),血清胃动素水平显著高于治疗前(P <0.05)。治疗后,观察组腹泻、恶心呕吐、腹痛缓解时间显著低于对照组(P <0.05),观察组中医症候积分、血清胃泌素水平、TNF-α、TGF-β1、IL-6水平显著显著低于对照组(P <0.05),血清胃动素水平高于对照组(P <0.05)。结论:疏肝利胆和胃汤联合西咪替丁可有效改善肝胃不和型急性胃炎患者血清胃泌素、胃动素水平,降低炎性因子水平,提高临床疗效。
Objective： To observe the clinical effect of Shugan Lidan Hewei tang combined with cimetidine for acute gastritis of liver-stomach disharmony type. Methods, Selected 116 cases of patients with acute gastritis of liver-stomach disharmony type, and divided them into the observation group and the control group randomly, 58 cases in each group. Both groups received the routine treatment, and the control group additionally received cimetidine, while the observation group additionarly received Shugan Lidan Hewei tang based on the treatment for the control group. One course of treatment lasted for 4 weeks. Observed Chinese medicine syndrome scores, the symptom abatement time and clinical effect in both groups, and detected the levels of gastrin, motilin, tumour necrosis factor-α （TNF-α）, transforming growth factor-β1 （TGF-β1） and interleukin-6 （IL-6） in serum. Results： The total effective rate was 93.10% in the observation group, being significantly higher than 79.31% in the control group （P 〈 0.05）. Before treatment, comparing Chinese medicine syndrome scores, the levels of gastrin, motilin, TNF-α, TGF-β1 and IL-6 in serum of both groups, there were no significant differences being found （P 〉 0.05）. After treatment, Chinese medicine syndrome scores, the levels of gastrin, TNF-α, TGF-β1 and IL-6 in serum of both groups were significantly lower than those before treatment （P 〈 0.05）, and the level of motilin in serum was significantly higher than that before treatment （P 〈 0.05）. After treatment, the abatement time of diarrhea, nausea, vomiting and abdominal pain in the observation group was evidently lower than that in the control group （P 〈 0.05）, Chinese medicine syndrome scores, the levels of gastrin, TNF-α, TGF-β1 and IL-6 in serum of the observation group were evidently lower than those in the control group（P 〈 0.05）, and the level of motilin in serum was evidently higher than that in the control group （P 〈 0.05）, Conclusion： Shugan Lidan Hewei t
作者
林琳
沈昱颖
钟琴娟
马海涛
LIN Lin;SHEN Yuying;ZHONG Qinjuan;MA Haitao
出处
《新中医》
CAS
2018年第11期94-98,共5页
New Chinese Medicine
基金
浙江省自然科学基金资助项目(LY16H130008)
关键词
急性胃炎
肝胃不和型
疏肝利胆和胃汤
西咪替丁
临床疗效
炎性因子
Acute gastritis
Liver-stomach disharmony type
Shugan Lidan Hewei tang
Cimetidine
Clinical effect
Inflammatory factors
