摘要
目的探讨应用芪血颗粒联合琥珀酸亚铁治疗女性缺铁性贫血的临床效果。方法选取2016年6月—2017年10月渭南市妇幼保健院收治的女性缺铁性贫血患者130例,随机分成对照组(65例)和治疗组(65例)。对照组饭后口服琥珀酸亚铁片,2片/次,2次/d。治疗组在对照组基础上口服芪血颗粒,1袋/次,3次/d。两组患者均连续治疗8周。观察两组患者临床疗效,同时比较治疗前后两组患者血象指标、铁代谢指标和免疫功能。结果治疗后,对照组临床有效率为80.0%,显著低于治疗组的92.3%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血红蛋白(Hb)、平均血红蛋白量(MCH)和平均体积(MCV)均显著增加(P<0.01),红细胞体积分布宽度(RDW)显著减少(P<0.01),且治疗后治疗组这些血象指标改善更明显(P<0.01)。治疗后,两组血清铁(SI)、血清铁蛋白(SF)水平较治疗前均显著升高(P<0.01),总铁结合力(TIBC)、血清转铁蛋白受体(s TFR)水平均显著减少(P<0.01),且治疗后治疗组铁代谢指标明显优于对照组(P<0.01)。治疗后,两组外周血CD4^+值和CD4^+/CD8^+比值较治疗前均显著上升(P<0.01),CD8^+值显著下降(P<0.01),且治疗后治疗组免疫功能明显优于对照组(P<0.01)。结论芪血颗粒联合琥珀酸亚铁治疗女性缺铁性贫血可有效缓解患者贫血症状,改善红细胞形态,疗效显著,且安全性高。
Objective To investigate the clinical effect of Qixue Granules combined with ferrous succinate in treatment of female iron deficiency anemia.Methods Patients（130 cases）with iron deficiency anemia in Weinan Maternal and Child Health Hospital from June 2016 to October 2017 were randomly divided into control（65 cases）and treatment（65 cases）groups.Patients in the control group were po administered with Ferrous Succinate Tablets,2 tablets/time,twice daily.Patients in the treatment group were po administered with Qixue Granules on the basis of the control group,1 bag/time,three times daily.Patients in two groups were treated for 8 weeks.After treatment,the clinical efficacy was evaluated,and the hematological parameters,iron metabolism indicators,and immune function in two groups before and after treatment were compared.Results After treatment,the clinical efficacy in the control group was 80.0%,which was significantly lower than 92.3%in the treatment group,and there were differences between two groups（P〈0.05）.After treatment,the Hb,MCH,and MCV levels in two groups were significantly increased（P〈0.01）,but RDW levels were significantly decreased（P〈0.01）,and these indicators in the treatment group were significantly better than those in the control group（P〈0.01）.After treatment,SI and SF levels in two groups were significantly increased（P〈0.01）,but TIBC and s TFR levels were significantly decreased（P〈0.01）,and the iron metabolism indicators in the treatment group were significantly better than those in the control group（P〈0.01）.After treatment,the CD4＋and CD4＋/CD8＋of peripheral blood in two groups was significantly increased（P〈0.01）,but CD8＋of peripheral blood was significantly decreased（P〈0.05）,and the immune function in the treatment group was significantly better than those in the control group（P〈0.05）.Conclusion Qixue Granules combined with ferrous succinate in treatment of female iron deficiency anemia can effectively alleviate the sympt
作者
李彩娟
雷彦平
LI Cai-juan;LEI Yan-ping(Department of Obstetrics and Gynecology,Weinan Maternal and Child Health Hospital,Weinan 714000,China;Department of Pharmacy,Weinan Maternal and Child Health Hospital,Weinan 714000,China)
出处
《现代药物与临床》
CAS
2018年第10期2686-2690,共5页
Drugs & Clinic
