摘要
目的:探讨血清水通道蛋白4(AQP-4)抗体检测在视神经脊髓炎患者中的应用价值。方法:选取2016年8月-2017年8月本院收治的视神经脊髓炎患者84例为研究A组、多发性硬化患者84例为研究B组、体检正常人84例为对照组。三组均进行血清AQP-4抗体水平检测。比较三组AQP-4阳性率,比较研究组首发受累部位、不同性别患者AQP-4抗体阳性率。结果:研究组AQP-4阳性率高于对照组,且研究A组高于研究B组,比较差异均有统计学意义(P<0.05);研究A组各首发受累部位例数均多于研究B组(P<0.05);女性AQP-4抗体阳性率高于男性(P<0.05)。结论:血清AQP-4抗体水平与视神经脊髓炎紧密相关,是区分神经脊髓炎与多发性硬化的重要物质,临床利用价值与推广价值较高。
Objective：To explore the application value of serum aquaporin-4 antibody（AQP-4） in patients with neuromyelitis optica.Method：A total of 84 patients with neuromyelitis optica admitted to our hospital from August 2016 to August 2017 were selected as study A group,84 patients with multiple sclerosis as study B group and 84 healthy persons as control group.Serum AQP-4 antibody levels were detected in three groups.The positive rate of AQP-4 was compared between three groups,the first involvement site in study group were compared,the positive rate of AQP-4 antibody of different sex patients in study group was compared.Result：The positive rate of AQP-4 in study group was higher than that of control group,and that in study A group was higher than that of study B group,the differences were statistically significant（P〈0.05）.The number of first involvement site in study A group was more than those of study B group（P〈0.05）.The positive rate of AQP-4 antibody in females was higher than that of males（P〈0.05）.Conclusion：Serum AQP-4 antibody level is closely related to neuromyelitis optica,it is an important substance to distinguish neuromyelitis from multiple sclerosis,has high clinical value and promotion value.
作者
李文强
梁成
LIWenqiang;LIANG Cheng(Second Hospital ofLanzhou University,Lanzhou730030,China)
出处
《中国医学创新》
CAS
2018年第33期117-120,共4页
Medical Innovation of China
