摘要
目的探讨颅咽管瘤切除术后并发癫痫的危险因素。方法选取本院2015年1月至2017年12月行颅咽管瘤切除术的169例患者为研究对象,依据患者癫痫发生情况将其分为观察组(术后并发癫痫,42例)和对照组(术后未并发癫痫,127例),收集两组患者的临床资料及手术相关资料,采用多因素Logistic回归分析确定颅咽管瘤切除术后并发癫痫的危险因素,采用接受者操作特征曲线(receiver operating characteristic curve,ROC曲线)分析确定其最佳界定值。结果 169例患者中,合并术后癫痫42例,术后癫痫发生率为24.85%。其中年龄<11岁、病程> 6个月、合并高钠血症、低钠血症、低钙血症及肿瘤直径> 4.65 cm、病变位于鞍内和鞍上、术后血肿均为颅咽管瘤术后并发癫痫的危险因素(P_均<0.05)。结论颅咽管瘤切除术后并发癫痫主要与患者手术时年龄、病程、合并高钠血症、低钠血症、低钙血症、肿瘤直径、病变部位及术后血肿相关,对上述危险因素尽早干预,有助于降低颅咽管瘤切除术后并发癫痫的风险。
Objective To investigate the risk factors of epilepsy after craniopharyngioma excision. Method 169 patients who underwent crmliopharyngioma resection from January 2015 to December 2017 were selected as the study subjects. According to the incidence of epilepsy, they were divided into observation group （42 cases） and control group （127 cases）. The clinical data of the two groups were collected and compared. Multivariate Logistic regression analysis was used to determine the risk factors of postoperative epilepsy. The course of disease and tumor diameter data were determined by receiver operating characteristic curve （ROC curve） analysis. The best defined value was determined by ROC curve. Result Among 169 patients, 42 cases complicated with postoperative epilepsy, and the incidence of postoperative epilepsy was 24.85%. Among them, age 〈 11 years old, the course of disease 〉 6 months, combined with hypernatxemia, hyponatxemia or hypocalcemia, tumor diameter 〉 4.65 cm, the lesion located in the sella and suprasella, postoperative hematoma were the risk factors of epilepsy after craniopharyngioma excision （Pall 〈0.05）. Conclusion Epilepsy after craniopharyngioma resection are mainly associated with the patients＇ age of operation, the course of disease, combined with hypernatxemia, hyponatxemia or hypocalcemia, the tumor diameter, the lesion location and postoperative hematoma. These risk factors should be intervened as soon as possible to reduce the risk of epilepsy after craniopharyngioma resection.
作者
王常贞
吴大号
林涛
朱贵东
徐坤
李卓
王瑞英
WANG Chang-zhen;WU Da-hao;LIN Tao;ZHU Gui-dong;XU Kun;LI Zhuo;WANG Rui-ying(Departent of Neurosurgery,Shandong Provincial Hospital,Jinan 250021,China)
出处
《中国医学前沿杂志（电子版）》
2018年第11期98-101,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
关键词
颅咽管瘤
癫痫
危险因素
切除术
Craniopharyngioma
Epilepsy
Risk factor
Excision
