摘要
目的检测颅咽管瘤组织中整合素αvβ3的表达,并观察其与肿瘤复发的关系。方法本研究包括32例釉质上皮型(AE)和33例鳞状乳头型(SPT)颅咽管瘤病例,根据各组术后复发情况再分为复发组和非复发组,采用免疫组化(SABC法)测定整合素αvβ3在各组中的表达情况。结果 32例AE型组11例患者复发,33例SPT型组3例患者复发。AE型组与SPT型组间复发率和整合素αvβ3表达差异均有统计学意义(P<0.01);各组中复发组与非复发组间整合素αvβ3表达差异有统计学意义(P<0.01)。结论颅咽管瘤的病理亚型和整合素αvβ3的表达与肿瘤预后及复发有关,可能预测肿瘤复发危险性。
Objective To investigate the expression of integrin alphavbeta3（αvβ3） in craniopharyngioma tissues and observe the relation between expression and recurrence of craniopharyngiomas.Methods A total of 32 adamantine epithelioma（AE） patients and 33 squamous papillary tumor（SPT） patients included in the study were divided into recurrence group and recurrence-free group.The expression of αvβ3 protein was evaluated in each group by immunohistochemical method（streptavidin-biotin-peroxidase）.Results Recurrence occurred in 11 of 32 AE patients and 3 of 33 SPT patients during the follow-up.There was significant difference in αvβ3 protein expression and recurrence rate between AE group and SPT group（P0.01）.Expressions of αvβ3 protein were significantly different between recurrence group and recurrence-free group（P0.01）.Conclusion The subtypes of craniopharyngiomas and expression of αvβ3 protein are associated with the prognosis and recurrence of tumor,which may be used as a predictor for recurrence of tumor.
出处
《中华神经外科疾病研究杂志》
CAS
2011年第4期330-333,共4页
Chinese Journal of Neurosurgical Disease Research
关键词
颅咽管瘤
整合素
ΑVΒ3
预后
Craniopharyngioma
Integrin
Alphavbeta3
Prognosis
