摘要
目的比较低剂量索他洛尔与普罗帕酮治疗心律不齐的效果及改善QTd的作用。方法选择我院2017年1月至2018年1月收治的86例心律不齐患者为研究对象,将其随机分成对照组和研究组,每组43例。对照组采用普罗帕酮治疗,研究组采用低剂量索他洛尔治疗。比较两组患者的QTd、心功能指标水平、临床疗效及不良反应发生情况。结果治疗后,两组患者的QTd均下降,且研究组明显低于对照组(P<0.05);两组患者的LVESD、LVEDD水平均明显下降,LVEF水平明显上升,且研究组的LVESD、LVEDD水平明显低于对照组,LVEF水平明显高于对照组(P<0.05);研究组患者的治疗总有效率略高于对照组,但差异无统计学意义(P>0.05);两组患者治疗期间的不良反应总发生率无显著差异(P>0.05)。结论对心律不齐患者采用低剂量索他洛尔与普罗帕酮治疗,均有良好的疗效,且不良反应发生率较低,但低剂量索他洛尔对改善患者QTd、心功能指标水平的效果优于普罗帕酮,因此,临床可优先选择低剂量索他洛尔进行治疗。
Objective To compare the effect of low dose sotalol and propafenone on arrhythmia and improvement ofQTd. Methods Eighty-six patients with arrhythmia treated in our hospital from January 2017 to January 2018 were selectedas study subjects and randomly divided into control group and study group, with 43 cases in each group. The control groupwas treated with propafenone, and the study group was treated with low-dose sotalol. The QTd, cardiac function indexes,clinical effect and occurrence of adverse reactions in the two groups were compared. Results After treatment, the QTd inthe two groups decreased, and that in the study group was significantly lower than the control group （P〈0.05）; the levels ofLVESD and LVEDD significantly decreased, the levels of LVEF were significantly increased in the two groups, and thelevels of LVESD and LVEDD in the study group were significantly lower than those of the control group, the level of LVEFwas significantly higher than that of the control group（P〈0.05）. The total effective rate of treatment in the study group wasslightly higher than that of the control group, but there was no significant difference（P〉0.05）, there was no significantdifference in the total incidences of adverse reactions between the two groups during treatment（P〉0.05）. Conclusion Bothlow -dose sotalol and propafenone have good therapeutic effect on arrhythmia patients, and the incidence of adversereactions are low, but the effect of low-dose sotalol on improving QTd and cardiac function index is better than that ofpropafenone. Therefore, low-dose sotalol can be preferred in clinical treatment.
作者
燕利
杜亚坤
YAN Li;DU Ya-kun(Traditional Chinese Medicine Hospital of Huyi District,Xi＇an,710300;Hanzhong People＇s Hospital,Hanzhong 723000,China)
出处
《临床医学研究与实践》
2018年第32期45-47,共3页
Clinical Research and Practice
