摘要
目的:比较女方年龄以及常规体外受精(IVF)和卵胞浆内单精子注射(ICSI)两受精方式对获单卵周期患者助孕结局的影响。方法:回顾分析IVF或ICSI助孕治疗获卵数仅为单个的患者的临床资料,分别比较不同年龄组(<30岁组、30～34岁组、35～38岁组和>38岁组)以及常规IVF和ICSI组的受精率、卵裂率、优质胚胎率、可用胚胎率、妊娠率、早期流产率、移植周期取消率等情况。结果:获单卵周期的不同年龄组患者的受精率、卵裂率、优质胚胎率、可用胚胎率、妊娠率、早期流产率、移植周期取消率比较差异无统计学意义(P>0.05),其胚胎冷冻率差异有统计学意义(P<0.05)。另外,行常规IVF和ICSI的获单卵周期的优质胚胎率、妊娠率、早期流产率、胚胎冷冻率和移植周期取消率比较差异无统计学意义(P>0.05);但常规IVF组的受精率和卵裂率均高于ICSI组,差异具有统计学意义(P<0.05);而IVF组的可用胚胎率要低于ICSI组,差异具有统计学意义(P<0.05)。结论:对获单卵周期而言,女方年龄增加导致胚胎冷冻率升高,但并不影响胚胎质量;另外ICSI授精并不能改善获单卵周期的助孕结局,需根据处理后的精液情况优先选择常规IVF授精。
Objective：To compare the effects of maternal age and two different fertilization methods including in vitro fertilization and intracytoplasmic sperm injection on the outcomes of the single oocyte retrieval cycles. Methods：This was a retrospective analysis of the clinical data from patients who only retrieved one oocyte in each IVF or ICSI treatment cycle in reproduction center. We compared the fertilization rate,cleavage rate, high quality embryo rate,available embryo rate, pregnancy rate, early abortion rate and transfer cycle cancellation rate of different age groups including age〈30 , age between 30 and 34, age between 35 and 38, and age〉38 and of conventional IVF or ICSI. Results：There were no significant differences in fertilization rate,cleavage rate, high quality embryo rate, available embryo rate, pregnancy rate, early abortion rate and transfer cycle cancellation rate of patients retrieved one oocyte in different age groups（ P 〉0.05）.While the embryo cryopreservation rate of different age groups were significantly different（ P 〈0.05）.Moreover, There were no significant differences in high quality embryo rate,pregnancy rate, early abortion rate ,embryo cryopreservation rate and transfer cycle cancellation rate of IVF or ICSI group of patients retrieved one oocyte（ P 〉0.05）. In addition, the fertilization rate andcleavage rate of conventional IVF group were statistically significantly higher than that of ICSI group（ P 〈0.05）. Nevertheless, available embryo rate of conventional IVF group was lower than that of ICSI group andthe difference was statistically significant （ P 〈0.05）. Conclusions：For single oocyte retrieval cycles, female age did not affect the quality of embryos, but resulted in the increasing of embryo cryopreservation rate. In addition, the pregnancy outcome of single oocyte retrieval cycles can’t be improved by ICSI. So according to theparameters after sperm processed conventional IVFis preferred.
作者
陈清汾
康跃凡
杜生荣
林典梁
Chen Qinfen;Kang Yuefan;Du Shengrong(Fujian Provincial Maternity and Children＇s Hospital,Affiliated Hospital of Fujian Medical University（Fuzhou 350001)
出处
《陕西医学杂志》
CAS
2018年第12期1584-1587,共4页
Shaanxi Medical Journal
关键词
年龄因素
体外受精
卵子发生
妊娠保持
Agefactors
Fertilization in vitro
Oogenesis
Pregnancy maintenancy
