摘要
目的研究0．1％溴芬酸钠水合物滴眼液在中、重度干眼治疗中的临床疗效。方法临床病例回顾性研究。选取2015年10月至2016年10月在我院眼科就诊的40例中、重度干眼患者，随机分成2组，每组20例，对照组应用0．1％玻璃酸钠滴眼液联合0．1％氟米龙滴眼液点眼，试验组应用0．1％玻璃酸钠滴眼液联合0．1％溴芬酸钠水合物滴眼液点眼。治疗前与治疗2周后均行眼表染色评分、泪膜破裂试验、泪液分泌试验检查、角膜共聚焦显微镜观察树突细胞密度。结果用药前及用药2周后试验组与对照组间的眼表染色评分、泪膜破裂时间、泪液分泌试验、角膜树突细胞密度差异均无统计学意义（P〉0．05），两组自身治疗前后的眼表染色评分、泪膜破裂时间、泪液分泌试验、角膜树突细胞密度均有明显改善，差异有统计学意义（P〈0．05）。结论0．1％溴芬酸钠水合物滴眼液可以在一定程度上替代糖皮质激素治疗中、重度干眼。
Objective To study the clinical efficacy of 0.1% bromfenac sodium eye drops in the treatment of moderate and severe dry eye. Methods A total of 40 cases of moderate and severe dry eye were randomly divided into 2 groups, 20 cases in each group, the control group of 20 cas-es using 0.1% Sodium Hyaluronate eye Drops and 0.1% Fluorometholone eye Drops, the test group of 20 cases were applied 0.1% Sodium Hyaluronate eye Drops and 0.1% bromfenac sodium eye Drops. Ocular surface staining, tear test, Schimmer I, corneal confocal microscope observation of den-dritic cell density was examined before treatment and after 2 weeks of treatment. Results There was no significant difference in the test group and the control group of ocular surface staining, tear test, tear secretion test, corneal dendritic cell density before treatment and after 2 weeks of treatment （P 〉0.05）, the test group before and after treatment of ocular surface staining, tear test, Schimmer I, corneal dendritic cell density was significantly improved, the difference was statistically significant （P 〈0.05）. Conclusions 0.1% bromfenac sodium eye Drops can be a certain degree of substitution of glucocorticoid in the treatment of moderate and severe dry eye.
作者
徐良
丁亚莉
Xu Liang;Ding Yali(Nanyang Eye Hospital,Nanyang 473000,China)
出处
《中国实用眼科杂志》
2017年第9期906-908,共3页
Chinese Journal of Practical Ophthalmology
