摘要
骨髓间充质干细胞（BMSCs）是一类具有多项分化潜能的干细胞,通过诱导BMSCs可分化为神经细胞.已有动物实验证明,BMSCs移植治疗能够使阿尔茨海默病（AD）脑内Aβ沉积减少、tau蛋白过度磷酸化水平,并逆转AD病理变化,移植修饰BMSCs,其治疗效果更好.其可能的机制有：刺激神经发生和突触的形成,分泌多种神经营养因子和细胞因子,发挥免疫调节作用.本文就BMSCs治疗阿尔茨海默病研究进展做一综述.
Bone marrow mesenchymal stem cells （BMSCs） is a kind of stem cells that have multiple differentiation potential. Through induced BMSCs can differentiate into neural cells. Animal experiments proved that BMSCs transplantation for treatment of Alzheimer＇s disease （AD） can reduce the β amyloid deposition, the level of tau protein phosphorylation, and reverse the AD pathological changes. Through the modification of BMSCs for treatment, the effect is better, and its possible mechanisms are stimulating neurogenesis and the formation of synapses, secreting various neurotrophic factors and cytokines for nerve protection, playing the role of immune regulation. This article reviews on the research progress of BMSCs in the treatment of Alzheimer＇s disease.
作者
王回
石晶
卞合涛
闫中瑞
Wang Hui;ShiJing;Bian Hetao;Yan Zhongrui(Department of Neurology,Jining NO.1 People＇s Hospital,Jining 272011,China;School of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan 250022,China)
出处
《中华脑科疾病与康复杂志（电子版）》
2017年第2期90-93,共4页
Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）
基金
山东省科学技术发展计划（2012GSF11838）
关键词
骨髓间充质干细胞
阿尔茨海默病
移植
Bone marrow mesenchymal stem cells
Alzheimer＇s disease
Transplant
