摘要
近年研究发现，星形胶质细胞可表达神经干细胞或神经前祖细胞的标记物，具有神经源性分化潜能。通过细胞转分化／基因重编程技术，将星形胶质细胞、特别是过度活化的反应性星形胶质细胞转分化为神经元，以修复受损的神经功能，已成为当下研究热点。本文围绕诱导星形胶质细胞转分化为神经元的转录因子及其调控作用综述如下。
More and more researches demonstrate that astrocytes display the markers of neural stem cells or progenitor cells and have the potential of neural differentiation. Thus, it is possible that astrocytes, especially overactive astrocytes, could replace injured neurons and repair the damaged function by transdifferenting and gene reprogramming. Here, we summarize recent progresses of various transcription factors and their regulation in astrocytes-to-neurons transdifferentiation.
作者
唐华娟
蔡雪梅
牛成慧
韩雁冰
Tang Huajuan;Cai Xuemei;Niu Chenghui;Hart Yanbing(Department of Neurology,First Affiliated Hospital of Kunming Medical University,Kunming 650032,Chin;Department of Laboratory Medicine,First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2018年第10期1059-1062,共4页
Chinese Journal of Neuromedicine
关键词
星形胶质细胞
转录因子
细胞转分化
基因重编程
Astrocyte
Transcription factor
Cell transdifferentiation
Oene reprogramming
