摘要
阿尔茨海默病（Alzheimer disease，AD）和血管性痴呆（Vascular denmntia，VD）是临床最常见的老年痴呆类型，但因缺乏有效的治疗措施而成为严重威胁老年人身心健康和生存质量的主要疾病之一。近来研究表明，Humanin（HN）具有广泛的神经保护作用，除能拮抗β淀粉样蛋白（amyloid beta，Aβ）引起神经细胞损伤外，还能保护缺血引起的PC12细胞的损伤，为开发特异性防治痴呆的新药物带来希望。本文就HN与AD、VD之间的研究进展做一综述。
Alzheimer disease and vascular dementia, known as the most common clinical types of dementia, have became one of the major disease that seriously threaten the physical and mental health and living quality of old people, because of the lack of effective treatment measures. Recent studies have shown that humanin has extensive nerve protective effect, such as lessening injury of PC12 cells caused by ischemia; besides restraining neuron damage caused by amyloid beta. Thus, humanin might bring hope to the development of specific new drugs for the prevention and control of dementia. In this paper, we review the advances in the research between humanin, Alzheimer disease and vascular dementia.
作者
张馨娜
王涛
李洪军
孙宝民
张新萍
Zhang Xinna,Wang Tao,Li Hongjun,Sun Baomin,Zhang Xinping(1.Department of Neurology, Taian City Central Hospital, Taian 271000,Shandong, China;2.Department of Clinical Psychology, Taian City Central Hospital, Taian 271000, Shandong, China;3.Corresponding author：Zhang Xinping,Email：immunology@163.co)
出处
《中华脑科疾病与康复杂志（电子版）》
2017年第1期32-35,共4页
Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）
基金
山东省医药卫生科技发展计划项目（2015WS0119）
