摘要
Humanin(HN)是在阿尔茨海默病(Alzheimer’s disease,AD)患者大脑枕叶皮层未受损的脑区发现的一种由24个氨基酸组成的线性多肽,能有效抑制多种家族性阿尔茨海默病(familial Alzheimer’s disease,FAD)基因突变和β-淀粉样肽(β-amyloid peptide,Aβ)诱发的神经元凋亡,起初被认为是AD特异性的神经保护肽。然而近年来研究发现,humanin具有广谱的神经保护、细胞保护与抗炎作用,可改善胰岛素敏感性,延缓糖尿病的发生。Humanin在多种疾病模型中,如AD、2型糖尿病、动脉粥样硬化、心肌缺血、脑卒中等发挥保护作用,在以上疾病的防治中可能具有重要意义。
Humanin（HN）, a 24-amino-acid polypeptide, was first identified from the surviving neurons in occipital lobe of Alzheimer＇s disease（AD） patients. Humanin inhibits neuronal cell death induced by various kinds of familial Alzheimer＇s disease gene mutations and β-amyloid peptide, which was thought to be an AD specific neuroprotective peptide at first. However, many recent studies demonstrated that humanin possesses diverse neuroprotective, cytoprotective and anti-inflammatory effects. Meanwhile, humanin can also improve insulin sensitivity, then delay onset of diabetes. Humanin offers protection in many disease models, such as AD, type 2 diabetes mellitus, atherosclerosis, myocardial ischemia, stroke and so on. Humanin probably plays important roles in the prevention and treatment of these diseases.
出处
《中国细胞生物学学报》
CAS
CSCD
2015年第3期433-440,共8页
Chinese Journal of Cell Biology
