摘要
目的探究不同剂型黄体酮治疗功能性子宫出血的临床疗效,并分析其药物经济效应。方法将108例功能性子宫出血患者随机均分为三组,患者均在服用戊酸雌二醇基础上给予黄体酮治疗,其中A组给予黄体酮阴道凝胶,B组给予黄体酮栓,C组给予黄体酮胶囊。比较三组的临床疗效及不良反应发生情况,并进行药物经济学分析。结果 B组治疗总有效率明显高于A组和C组(P<0.05)。C组不良反应总发生率明显高于A组和B组(P<0.05)。三组成本比较,A组>C组>B组;三组成本-效果比比较,A组>C组>B组。结论在功能性子宫出血的治疗中,黄体酮栓可有效提高临床治疗效果,且最为经济,值得推广。
Objective To explore the clinical efficacy of different forms of progesterone in the treatment of dysfunctional uterine bleeding and to analyze their pharmacoeconomics. Methods A total of 108 patients with dysfunctional uterine bleeding were randomly divided into three groups. All patients were given progesterone treatment on the basis of estradiol valerate. Group A was given progesterone vaginal gel, group B was given progesterone suppository, and group C was given progesterone capsule. The clinical efficacy and adverse reactions of the three groups were compared, and their pharmacoeconomic analyses were performed. Results The total effective rate of treatment in the group B was significantly higher than that in the group A and group C （P〈0.05）. The total incidence of adverse reactions in the group C was significantly higher than that in the group A and group B （P〈0.05）. The cost order among the three groups was group A〉 group C〉group B; and the cost-effect ratio order among the three groups was group A〉group C〉group B. Conclusion In the treatment of dysfunctional uterine bleeding, progesterone suppository can effectively improve the clinical efficacy and is the most economical treatment method, which is worthy of promotion.
作者
苏丽娟
李艳文
SU Li-juan;LI Yan-wen(Shaanxi Friendship Hospital,Xi＇an 710068;Northwest University Hospital,Xi＇an 710069,China)
出处
《临床医学研究与实践》
2018年第31期92-93,共2页
Clinical Research and Practice
关键词
黄体酮
功能性子宫出血
药物经济学
progesterone
dysfunctional uterine bleeding
pharmacoeconomic
