摘要
目的：探讨不同剂型黄体酮治疗功能性子宫出血的临床效果及药物经济学评价。方法选择本院2012年7月～2013年7月收治的114例功能性子宫出血患者，随机分为观察组、实验组和对照组各38例，对照组患者采用黄体酮阴道凝胶治疗，实验组患者采用黄体酮胶囊治疗，观察组患者采用黄体酮栓治疗。对比分析3组的治疗效果及药物经济学评价。结果观察组和对照组总有效率高于实验组，差异有统计学意义（P〈0.05），观察组与对照组的总有效率差异无统计学意义（P〉0.05）。观察组成本-效果比为76.69，实验组为322.04，对照组1547.71，实验组与对照组相对于观察组的增量成本-效果比分别为-1015.5、19748.61。结论黄体酮栓治疗功能性子宫出血的临床效果明显，经济学指标最佳，具有临床应用价值。
Objective To explore the efficacy and safety of different dosage form progestin in treatment of dysfunctional uterine bleeding and pharmacoeconomics evaluation. Methods 114 cases of patients with dysfunctional uterine bleeding treated in our hospital from July 2012 to July 2013 were selected,and were randomly divided into observation group,ex-perimental group and control group,38 cases in each group,control group were taken with progesterone vaginal gel,ex-perimental group were taken with progesterone suppository,observation group were taken with progesterone capsules.The effect of three groups and pharmacoeconomics evaluation was analyzed. Results The total effective rate of observation group and control group was higher than that of experimental group,the difference was significant （P〈0.05）,but there was no significant difference between observation group and control group （P〉0.05）.The cost-effectiveness ratio of observa-tion group,experimental group and control group was 76.69,322.04 and 1547.71,respectively.The increment of cost-ef-fectiveness of experimental group and control group was -1015.5 and 19 748.61. Conclusion Progesterone suppository has best effect in treatment of dysfunctional uterine bleeding,has clinical application value.
出处
《中国当代医药》
2015年第2期121-122,125,共3页
China Modern Medicine
