摘要
目的 探讨免疫防龋和氟化物防龋对学龄前儿童乳牙龋的预防效果及其对唾液中链球菌菌群的影响.方法 选择2014年1月至2016年12月杭州市江干区幼儿园360例儿童作为研究对象,将其根据随机数字表法分为免疫防龋组、氟化物放龋组和对照组,每组120例.免疫防龋组每天给予抗变异链球菌免疫球蛋白喷剂治疗;氟化物防龋组每6个月给予全口涂多乐氟氟化钠;对照组不做任何处理.观察患儿防龋治疗前后患龋情况,荧光定量聚合酶链反应测定口腔链球菌、唾液链球菌、血链球菌和戈登链球菌的数量.结果 防龋治疗前,免疫防龋组、氟化物防龋组和对照组患龋率分别为17.5％、15.8％、17.2％,免疫防龋组、氟化物防龋组和对照组患龋率比较差异无统计学意义（χ2=0.273,P〉0.05）;防龋治疗后,免疫防龋组、氟化物防龋组和对照组患龋率分别为23.3％、25.8％、40.8％,免疫防龋组和氟化物放龋阻患龋率低于对照组（χ2=10.238,P〈0.05）,免疫防龋组和氟化物放龋组患龋率比较差异无统计学意义（χ2=0.202,P〉0.05）;防龋治疗前,免疫防龋组、氟化物防龋组和对照组唾液中口腔链球菌、唾液链球菌、血链球菌和戈登链球菌比较差异均无统计学意义（F=1.037、1.215、1.426、0.924,均P〉0.05）;防龋治疗后,免疫防龋组口腔链球菌和戈登链球菌均高于氟化物防龋组和对照组（F=42.132、64.217,均P〈0.05）,免疫防龋组唾液链球菌和血链球菌均低于氟化物放龋阻和对照组（F=47.382、38.546,均P〈0.05）,氟化物防龋组和对照组唾液中口腔链球菌、唾液链球菌、血链球菌和戈登链球菌比较差异均有统计学意义（t=31.245、26.435、38.536、22.457,均P〈0.05）.结论 免疫防龋和氟化物防龋都能有效降低儿童的患龋率,免疫防龋对唾液中链球菌菌群有影响,氟化物防龋不影响唾液中链球菌菌群.
Objective To investigate the preventive effect of immune anti-caries and fluoride anti-caries on deciduous caries in preschool children and its effect on streptococcus in saliva.Methods From January 2014 to December 2016,360 children in Jianggan District of Hangzhou were collected in this research,and they were divided into immune anti-caries group,fluoride anti-caries group and control group according to random number method,with 120 cases in each group.The children of immune anti-caries group were given daily anti-Streptococcus immunoglobulin spray treatment.The children of fluoride anti-caries group were given DuoLe fluoride treatment every 6 months.The control group was not given any treatment.The caries of children with caries before and after treatment were observed.The oral Streptococcus,Streptococcus salivarius,Streptococcus and Streptococcus gondii were determined by fluorescence quantitative polymerase chain reaction.Results Before anti-caries treatment,the caries rates in the immune anti-caries group,fluoride anti-caries group and control group were 17.5%,15.8%and 17.2%,respectively,there was no statistically significant difference among the three groups（χ2 =0.273,P〉0.05）.After caries treatment,the caries rates of the immune anti-caries group,the fluoride anti-caries group and control group were 23.3%,25.8%,40.8%,respectively,the caries rate of the immune anti-caries group and the fluoride anti-caries group were lower than that of the control group（χ2 =10.238,P 〈0.05）,there was no statistically significant difference in the caries rate between the immune anti-caries group and the fluoride anti-caries group（χ2 =0.202,P〉0.05）.Before immune anti-caries treatment,there were no statistically significant differences in Streptococcus oralis,Streptococcus salivarius,Streptococcus sanguis and Streptococcus gondii among the three groups（F=1.037,1.215,1.426,0.924,all P〉0.05）.After treatment with caries,the Streptococcus oralis and Streptococcus grisea in the immune anti-caries group wer
作者
许赛君
Xu Saijun(Department of Stomatology,the People ＆ Hospital of Jianggan District,Hangzhou,Zhejiang 310021,China)
出处
《中国基层医药》
CAS
2018年第19期2478-2481,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
龋齿
氟化物
链球菌
儿童
Dental caries
Fluoride
Streptococcus
Children
