摘要
探索藏医治疗脾胃病的组方用药规律，分析其方剂可能存在的药物靶标及相互作用，揭示藏医治疗脾胃病的作用机制。收集藏医治疗脾胃病的方剂，采用中医传承辅助平台（TCMISS）分析药物间的关联规则，挖掘核心药物及新处方；借助整合药理学平台V1.0软件的分析功能构建“药物-化合物-靶点”网络，并研究藏药五味石榴散治疗脾胃病各药物靶标间的相互作用关系及其相关通路。在藏医治疗脾胃病216首方剂中，石榴子出现的频次最高（118次），其次是白豆蔻（107次）、荜茇（107次）等；利用关联规则（支持度≥34％，置信度≥0．85）演化得出藏医治疗脾胃病12首新处方；经典方藏药五味石榴散中的药物靶标5 242个，通路20条（FDR〈0．01）。提出藏医治疗脾胃病以增生“胃火”为思路，以理气健脾为主药，其作用机制可能是通过调控消化液、质子泵、线粒体以及机体对微生物的免疫功能等多靶标、多通路共同干预实现。
To explore the medication regularity of Tibetan medicine in the treatment of spleen and stomach diseases, analyze the potential drug targets and interactions of the prescriptions, and reveal the mechanism of Tibetan medicine in the treatment of spleen and stomach diseases. The prescriptions in Tibetan medicine for treatment of spleen and stomach diseases were collected, and Traditional Chinese Medicine Inheritance Support System （TCMISS） was used to analyze the association rules between the herbs and discover the core herbs and new prescriptions. The integrated pharmacology platform V1.0 software was used to construct ＂herb-compound-target＂ network and investigate the interactions between various herbs and related pathways of Tibetan medicine Wuwei Shiliu powder in the treatment of spleen and stomach diseases. Among the 216 prescriptions of Tibetan medicine in the treatment of spleen and stomach diseases, pomegranate seed was used at a highest frequency （118 times） , followed by white cardamom （107 times） and comatose （107 times ）. 12 new prescriptions were evolved by using the association rules （support≥34% , confidence≥0.85 ）. 5 242 related drug targets and 20 related pathways were obtained from classic formula Wuwei Shiliu Powder （ FDR 〈 0.01 ）. It was proposed that Tibetan medicine treatment for spleen and stomach diseases was mainly based on proliferation of ＂stomach fire＂ and the main drugs were for regulating Qi-flowing for strengthening spleen. The mechanism may be associated with regulation of digestive juice secretion, protonpump, mitochondria, regulation of intestinal digestion and immunity, the body＇s immunity to microorganisms function and other multipie targets and pathways to achieve the joint intervention.
作者
贡保东知
罗晴方
余羊羊
文成当智
曾商禹
刚焕晨雷
张艺
GONGBAO Dong-zhi,LUO Qing-fang,YU Yang-yang,WENCHENG Dang-zhi,ZENG Shang-yu,GANGHUAN Chen-lei,ZHANG Yi(College of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2018年第16期3368-3375,共8页
China Journal of Chinese Materia Medica
基金
国家社会科学基金重大项目(16ZDA238)
关键词
藏医
脾胃病
数据挖掘
组方用药规律
整合药理学
Tibetan medicine
spleen and stomach
disease
data mining
prescription rule of drug use
integrated pharmacology
