摘要
目的探讨丹红注射液联合注射用阿替普酶治疗急性脑梗死的临床疗效。方法选取2015年10月—2017年10月核工业四一六医院接收的急性脑梗死患者120例作为研究对象,将所有患者随机分为对照组和治疗组,每组各60例。对照组在发病24 h之内给予注射用阿替普酶,0.9 mg/kg,总剂量10%静脉推注,剩余剂量在随后60 min内持续静脉滴注。治疗组患者在对照组治疗的基础上静脉滴注丹红注射液,20 m L丹红注射液加入到5%葡萄糖注射液250 m L中,1次/d。两组患者均持续治疗14 d。观察两组的临床疗效,比较两组的脑梗死灶体积、急性期缺血半暗带体积、NIHSS评分和ADL评分。结果治疗后,对照组和治疗组的总有效率分别为85.00%、95.00%,两组比较差异有统计学意义(P<0.05)。治疗后,两组脑梗死灶体积明显小于急性期缺血半暗带,两组比较差异具有统计学意义(P<0.05);且治疗组脑梗死灶体积显著小于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组NIHSS评分显著降低,ADL评分显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标显优于对照组,两组比较差异有统计学意义(P<0.05)。结论丹红注射液联合注射用阿替普酶治疗急性脑梗死具有较好的临床疗效,可降低患者脑梗死灶体积,改善患者神经功能,提升日常生活质量,安全性较好,具有一定临床推广应用价值。
Objective To investigate the clinical effect of Danhong Injection combined with Alteplase for injection in treatment of acute cerebral infarction. Methods Patients（120 cases） with acute cerebral infarction in Nuclear Industry 416 Hospital from October 2015 to October 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were given Alteplase for injection within 24 h after the onset of the disease, 0.9 mg/kg, 10% of the total dose was intravenously injected, and the remaining dose was continuously iv injected within 60 min. Patients in the treatment group were iv administered with Danhong Injection on the basis of the control group, 20 m L added into 5% glucose solution 250 m L, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the volume of cerebral infarction area and acute ischemic penumbra, NIHSS scores, and ADL scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 85.00% and 95.00%, respectively, and there was difference between two groups（P 〈 0.05）. After treatment, the volumes of cerebral infarction area in two groups were less than the volumes of acute ischemic penumbra in two groups, and there was difference between two groups（P 〈 0.05）. And the volumes of cerebral infarction area in the treatment group were less than those in the control group, and there was difference between two groups（P 〈 0.05）. After treatment, the NIHSS scores in two groups were significantly decreased, but he ADL scores in two groups were significantly increased, and the difference was statistically significant in the same group（P 〈 0.05）. And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P 〈 0.05）. Conclusion Danhong Injection combined with Alteplase for injection has clinical curative
作者
段海宇
刘信东
杜鹃
张利娟
DUAN Hai-yu;LIU Xin-dong;DU Juan;ZHANG Li-juan(Department of Neurology,Nuclear Industry 416 Hospital,Chengdu 610000,China)
出处
《现代药物与临床》
CAS
2018年第9期2198-2201,共4页
Drugs & Clinic
