摘要
目的分析2016年河南省腹泻患者志贺菌感染的血清型分布及其耐药性。方法对2016年从河南省15家哨点医院中符合病例定义的2 896名患者的粪便中分离的50株志贺菌进行血清学分型,并采用肉汤稀释法进行药敏试验。结果 50株志贺菌以福氏志贺菌和宋内志贺菌2种血清型为主,其中福氏志贺菌2a型为引起食源性腹泻的主要病原菌菌型,占比52.0%(26/50),其次是宋内志贺菌II相,占比26.0%(13/50);耐药率最高的抗生素是萘啶酸(100.0%,50/50)和四环素(100.0%,50/50),其他依次为氨苄西林(98.0%,49/50)和甲氧苄氨嘧啶/磺胺甲噁唑(90.0%,45/50)。结论志贺菌多重耐药现象严重。
Objective Analyze the serotype distribution and drug resistance of Shigella from patients in Henan Province in 2016. Methods Fifty Shigella strains which were isolated from 2 896 diarrhea patients by 15 sentinel hospitals in Henan Province were tested for serotype and drug susceptibility with broth dilution method, and etiological food information were collected and analyzed statistically. Results Shigella flexneri and Shigella soonei were dominant serotype, among which Shigella flexneri 2 a subtype was the No.1 pathogens, accounted for 52.0%（26/50）, followed by Shigella soonei II phase accounted for 26.0%（13/50）. For drug susceptibility test for 10 kinds of antibiotics, the antibiotics with high resistance for Shigella included nalidixic acid（100.0%,50/50）, tetracycline（100.0%,50/50）, ampicillin（98.0%,49/50） and sulfonamide（90.0%,45/50）. Conclusion The multidrug resistance was serious.
作者
张濛
吴玲玲
李艳芬
张广伟
邱正勇
张秀丽
张丁
ZHANG Meng;WU Lingling;LI Yanfen;ZHANG Guangwei;QIU Zhengyong;ZHANG Xiuli;ZHANG Ding(Henan Center for Disease Control and Prevention,Henan Zhengzhou 450016,China)
出处
《中国食品卫生杂志》
北大核心
2018年第5期519-521,共3页
Chinese Journal of Food Hygiene
基金
河南省科技攻关项目(162102310310)
关键词
志贺菌
血清型分布
耐药
食源性致病菌
患者
河南
Shigella
serotype distribution
drug resistance
foodborne pathogen
patients
Henan
