摘要
目的：观察升降散加减联合针刺对肥胖相关性肾病（ORG）早期患者血清胱抑素C（CysC）、同型半胱氨酸（Hcy）及相关指标的影响,探讨其对肥胖肾损害患者早期肾功能的保护作用。方法：将符合诊断标准的92例早期ORG患者按随机数字表法分为观察组和对照组,每组各46例,对照组予坎地沙坦酯片8 mg,每日1次口服,观察组在对照组的基础上加用升降散加减联合针刺治疗,两组疗程均为3个月,3个月后比较治疗前后的收缩压（SBP）、舒张压（DBP）、体质量指数（BMI）、腰臀比（WHR）、CysC、Hcy、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、24 h尿微量清蛋白排泄率（UAER）、尿素氮（BUN）、肌酐（SCr）、β2微球蛋白（β2-MG）水平的变化。结果：观察组治疗后以上各指标除BUN、SCr无改善,其他较治疗前均明显改善（P〈0.05）,且与对照组比较差异有统计学意义（P〈0.05）;对照组治疗后SBP、DBP、BMI、WHR、UAER、CysC、Hcy、β2-MG与治疗前比较差异有统计学意义（P〈0.05）,其他指标无明显改善。结论：升降散加减联合针刺能够逆转和延缓肥胖对肾脏的早期损害,其机制可能与降低患者体质量、血脂及血压,改善肾脏血流动力学有关。
Objective：To observe the effect of adding or subtracting Shengjiang Powder combined with acupuncture on serum cystatin C（CysC）,homocysteine（Hcy） and other relevant indicators in patients with early obesity related nephropathy（ORG）,and to investigate its protective effecton early renal damage in patients with obesity. Methods：According to the diagnostic standard,total 92 patients with early ORG were randomly divided into treatment group and control group,46 cases in each group. Candesartan Cilexetil Tablets 8 mg was given orally 1 times a day in the control group. The treatment group used adding or subtracting Shengjiang Powder combined with acupuncture therapy based on the control group,two groups were treated for 3 months. After treatment,the changes of systolic blood pressure（SBP）,diastolic blood pressure（DBP）,bodymass index（BMI）,waist hip ratio（WHR）,CysC,Hcy,total cholesterol（TC）,threeglycerol（TG）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）,24 h urinaryalbumin excretion rate（UAER）,urea nitrogen（BUN）,creatinine（SCr）,β2-microglobulin（β2-MG） level in the 2 groups were compared. Results：After treatment,the above indicators were improved in the observation group except BUN and SCr（P〈0.05）,and the difference was statistically significant compared with control group（P〈0.05）.SBP,DBP,BMI,WHR,UAER,CysC,Hcy,β2-MG in the control group were significantly different from those before treatment（P〈0.05）,and other indicators were not significantly improved. Conclusion：Adding or subtracting Shengjiang Powder combined with acupuncture can reverse and delay the early damage of obesity to the kidney. The mechanism may be related to the reduction of body weight,blood lipids and blood pressure,and improvement of renal hemodynamics.
作者
宁志春
亢瑞娜
NING Zhichun;KANG Ruina(Luanxian Hospital of Traditional Chinese Medicine,Luanxian 063700,China;Tangshan Workers＇Hospital,Tangshan 063000,China)
出处
《山东中医药大学学报》
2018年第5期418-421,共4页
Journal of Shandong University of Traditional Chinese Medicine
基金
河北省中医药管理局2016年度中医药类科研计划项目(编号:2016242)
关键词
肥胖相关性肾病
升降散加减
针刺
胱抑素C
同型半胱氨酸
疗效观察
obesity related nephropathy
adding or subtracting Shengjiang Powder
acupuncture
cystatin C
homocysteine
observation on the therapeutic effect
