摘要
目的探讨低频重复经颅磁刺激(rTMS)联合认知疗法(CBT)治疗首发抑郁障碍的儿童的疗效。方法选取首发抑郁障碍且未接受过药物治疗的儿童90例,随机分为rTMS+CBP组30例、rTMS组30例及对照组(帕罗西汀组) 30例,评价治疗期间儿童抑郁量表(CDI)及不良反应量表(TESS)的变化,观察治疗前及治疗后第1、2、4、8周末患儿抑郁情况的变化及不良反应发生情况。结果 3组患儿经治疗后CDI评分较治疗前都有所下降(F=7. 759,P <0. 05),下降的幅度呈现rTMS+CBT组>rTMS组>对照组(F=12. 815,P <0. 01)。rTMS+CBT组及rTMS组不良反应发生率明显低于对照组(χ~2=4. 265、4. 336,P <0. 05),TESS评分也明显低于对照组(t=6. 620、6. 547,P <0. 05)。结论低频重复经颅磁刺激(rTMS)联合认知疗法较单纯重复经颅磁刺激及帕罗西汀治疗对抑郁症患儿更有效,不良反应发生率更低,临床值得推广。
Objective To investigate the efficacy of low-frequency repetitive transcranial magnetic stimulation （rTMS） combined with cognitive therapy （CBT） in the treatment of first-episode depressive disorder in children. Methods Ninety children with first-episode depressive disorder who were not treated with drugs were randomly divided into rTMS＋CBP group （30 cases）, rTMS group （30 cases） and control group （paroxetine group）, in order to evaluate the change of children′s depression scale （CDI） and side-response scale （TESS） during treatment, as well as the change of children′s depression scale （CDI） and side-response scale （TESS） during treatment and observe the change of the depression and the incidence of adverse reactions before and its effects after the first, second, fourth and eighth week. Results The CDI score of the three groups decreased after treatment （ F =7.759, P 〈0.05）, and the decreasing degree rank was rTMS ＋ CBT group〉 rTMS group〉 control group （ F = 12.815, P 〈0.01）. The incidence of adverse reactions in rTMS＋CBT group and rTMS group were significantly lower than that in control group （ χ 2 =4.265, 4.336, P 〈0.05）, and the TESS score was also significantly lower than that in control group （ t =6.620,6.547, P 〈0.05）. Conclusion Low frequency repetitive transcranial magnetic stimulation （rTMS） combined with cognitive therapy is more effective than simple repeat transcranial magnetic stimulation and paroxetine in children with depression, with a lower incidence of adverse reactions and worthy of clinical promotion.
作者
王鹭
冯虹
徐炯炯
董莹盈
曹士林
Wang Lu;Feng Hong;Xu Jiongjiong(The Recovery Unit of Shaoxing Seventh People′s Hospital,Zhejiang 312000,China)
出处
《医学研究杂志》
2018年第9期118-120,共3页
Journal of Medical Research
基金
浙江省医药卫生科技一般项目(2014KYB288)
绍兴市公益性技术应用研究项目(2015B70051)
关键词
儿童
抑郁症
经颅磁刺激
认知疗法
帕罗西汀
Child
Depression
Transcranial magnetic stimulation
Cognitive therapy
Paroxetine
