摘要
目的探讨皮肤细胞型蓝痣的临床病理学特征。方法对湘雅医院本部2017年2～11月间收治的2例皮肤细胞型蓝痣进行光镜观察和免疫组化检测。结果病变位于真皮,边界清楚,痣细胞为树突状或上皮样型,胞浆含黑色素颗粒或透明,呈团、巢、簇或单个弥散分布。免疫组化示痣细胞表达MelanA、HMB-45、S-100、Vimentin,不表达CKpan、H3K27M,Ki-67约1%阳性。结论皮肤细胞型蓝痣是一罕见、具有恶变倾向的病变,易与恶性黑色素瘤混淆,通过细致的组织形态学观察,Ki-67增殖指数的评估及临床资料综合分析可以明确,此病变宜适度扩大切除,深度须达皮下脂肪,以防复发。
Objective To investigate the clinicopathological features of skin cell type blue naevus. Methods Two cases of skin cell type blue naevus admitted in the Xiangya Hospital from February to November 2017 were examined by light microscopy and immunohistochemistry. Results The lesion was located in the dermis with clear boundaries. The sputum cells were dendritic or epithelial-like. The cytoplasm contained melanin particles or was transparent, showing clusters, nests, clusters or a single diffuse distribution. Immunohistochemistry showed that naevus cells expressed MelanA, HMB-45, S-100, Vimentin, and did not express CKpan, H3K27M, and the positive rate of Ki-67 was about 1%. Conclusion Skin cell type blue naevus is a rare malignant lesion, which is easily confused with malignant melanoma. And it can be made clear through careful histomorphological observation, the evaluation of Ki-67 proliferation index and comprehensive analysis of clinical data. This lesion should be moderately enlarged and excised to a depth of subcutaneous fat to prevent recurrence.
作者
杨玉兰
印惠
YANG Yulan;YIN Hui(Department of Pathology,Xiangya Changde Hospital in Hunan Province,Xiangya 415009,China;Department of Radiology,Xiangya Changde Hospital in Hunan Province,Xiangya 415009,China)
出处
《中国现代医生》
2018年第26期120-121,125,169,共4页
China Modern Doctor
