摘要
目的:探讨系统性红斑狼疮(SLE)对妊娠结局的影响。方法:收集2013年1月至2017年5月仁济医院收治的297例妊娠合并SLE患者作为研究组,并随机选择594例无妊娠合并症孕妇作为对照组,比较两组的妊娠结局。结果:在校正母亲年龄、地区、是否为初产妇、自发性流产史和合并症史混杂因素后,研究组的妊娠期高血压风险(OR=2.60,95%CI 1.60~4.22),子痫前期风险(OR=3.23,95%CI 1.88~5.55)、未足月胎膜早破风险(OR=2.50,95%CI 1.37~4.55)、胎儿丢失风险(OR=6.79,95%CI 2.89~15.92)、小于胎龄儿风险(OR=1.84,95%CI 1.04~3.28)、早产风险(OR=3.18,95%CI 2.12~4.77)、剖宫产儿风险(OR=4.19,95%CI 2.82~6.22)均显著高于对照组。结论:SLE显著增加孕产妇不良妊娠结局的风险。妊娠合并SLE孕妇应完善孕前评估、加强产前监测以改善妊娠结局。
Objective： To determine the effect of systemic lupus erythematous（ SLE） on pregnancy outcomes.Methods： A retrospective cohort study was performed in a tertiary medical center between January 2013 and May2017. 297 pregnancies with SLE and 594 pregnancies without SLE following randomly selection were included in the study.Results： The risks of pregnancy-induced hypertension（ OR = 2. 60,95% CI 1. 60-4. 22）,preeclampsia（ OR=3. 23,95%CI 1. 88-5. 55）,preterm premature rupture of membranes（ OR = 2. 50,95%CI 1. 37-4. 55）,fetal loss（ OR = 6. 79,95%CI 2. 89-15. 92）,small for gestational age（ OR = 1. 84,95%CI 1. 04-3. 28）,preterm birth（ OR=3. 18,95%CI 2. 12-4. 77）,cesarean section（ OR = 4. 19,95%CI 2. 82-6. 22） were significantly different between women with and without SLE after adjusting for confounding factors. Conclusions： SLE significantly increased the risk of adverse pregnancy outcomes. Therefore,a pre-conception assessment and close antenatal monitoring by both rheumatologists and obstetricians should be performed in pregnant women with SLE.
作者
吴珈悦
马京杭
张维宏
狄文
WU Jiayue;MA Jinghang;ZHANG Weihong(Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China;International Centre for Reproductive Health （ ICRH）, Ghent University, Ghent 9000, Belgium)
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2018年第9期712-715,共4页
Journal of Practical Obstetrics and Gynecology
基金
上海卫生和计划委员会课题(编号:15GWZK0701
2017ZZ02016)
关键词
系统性红斑狼疮
妊娠
母体结局
胎儿结局
Systemic lupus erythematosus
Pregnancy
Fetal outcomes
Maternal outcomes
