摘要
目的分析儿童气管支气管结核(tracheobronchial tuberculosis,TBTB)的临床相关因素及支气管镜下特点,为TBTB的早期诊断提供线索。方法回顾性分析2006年7月至2014年12月首都医科大学附属北京儿童医院收住人院并进行了支气管镜检查的肺结核患儿240例,最终根据支气管镜检查结果确诊TBTB130例(简称“TBTB组”),非TBTB的肺结核110例(简称“非TBTB组”)。对两组患儿的基本资料、临床表现、影像学特征、支气管镜下特点等进行分析比较。使用SPSS22.0软件进行统计学分析,计量资料采用秩和检验,计数资料采用y。检验,病灶位置的数目和年龄的相关性采用Spearman等级相关检验,P〈0.05为差异有统计学意义。结果TBTB组患儿的中位年龄[(1.6岁(四分位数:0.8岁,5.5岁)]显著低于非TBTB组[4.5岁(四分位数:1.1岁,10.1岁)](U=5309.500,P=0.001)。TBTB组年龄〈2岁的患儿占57.7%(75/130),高于非TBTB组的34.5%(38/110)(X^2=12.813,P=0.000)。喘息与气促症状的发生率在TBTB组(23.1%,30/130)显著高于非TBTB组(5.5%,6/110)(X^2=14.513,P=0.000)。TBTB组结核分枝杆菌培养阳性率(21.5%,28/130)显著高于非TBTB组(7.3%,8/110)(X^2=9.510,P=0.002)。TBTB组患儿胸部CT有22.3%(29/130)存在气道阻塞征象,显著高于非TBTB组(4.5%,5/110)(X^2=15.460,P=0.000)。通过支气管镜检查,TBTB组患儿淋巴结瘘型(1ymph node erosion,LNE)占95.4%(124/130),干酪样肺炎侵蚀破坏临近支气管(caseous pneumonia erosion,CPE)者占6.2%(8/130)。初次镜检时,77.7%(101/130)的TBTB患儿为淋巴结瘘型破溃期,17.7%(23/130)为淋巴结瘘型破溃前期。TBTB最常见累及右主支气管(33例)、右支气管中间段(32例)和右上叶支气管(30例)�
Objective We analyzed the associated clinical iactors and bronchoscoplc charactenstms ot children with Tracheobronchial tuberculosis (TBTB) to provide clues for the early diagnosis of tracheobronchial tuberculosis. Methods We retrospectively analyzed 240 cases of tuberculosis patients who had gone through bronchoscopy and been hospitalized in Beijing Children's Hospital, Capital Medical University between July 2006 and December 2014. In the end, 130 cases of TBTB ("TBTB group") and 110 cases of non-TBTB tuberculosis ("non-TBTB group") were confirmed according to the results of bronchoscopy. The general information, clinical symptoms, imaging features, and characteristics under bronchoscopy of the two groups were analyzed and compared. We used SPSS 22.0 statistical software for a Chi-square test and Spearman rank correlation test, with statistical significance of P〈0.05. Results The median age of the TBTB group (1.6 years old (Quartile: 0.8 years old, 5.5 years old)) was significantly lower than the non-TBTB group (4.5 years old (Quartile: 1.1 years old, 10. 1 years old)) (U=5309. 500,P=0. 001). The proportion of children younger than 2 years old in the TBTB group (75 cases, 57.7%) was significantly higher than in the non-TBTB group (38 cases, 34.5% ) (X^2=12. 813, P=0. 000). The incidence of wheezing and tachypnea in the TBTB group (23.1%, 30/130) was significantly higher than non-TBTB group (5.5%, 6/110) (X^2=14. 513, P= 0. 000). The positive rate of Mycobacterium tuberculosis culture in the TBTB group(21.5%, 28/130)was significantly higher than non-TBTB group(7. 3%, 8/110) (X^2=9. 510, P=0. 002). Among the TBTB group, 22.3 % (29/130) had airway obstruction on chest CT, which was significantly higher than non-TBTB group (4.5%, 5/110) (X^2= 15. 460, =0. 000). Results from the bronchoscopy showed that lymph node erosion (LNE) happened in 95.4% (124/130) of the TBTB group, and caseous pneumonia erosion (CPE)
作者
刘芳
申晨
孙琳
饶小春
马渝燕
孟辰芳
潘跃娜
李干
焦安夏
LIU Fang;SHEN Chen;SUN Lin;RAO Xiao-chun;MA Yu-yan;MENG Chen-fang;PAN Yue-na;LI Can;JIAO An-xia(Interventional Pulmonology Department,China National Clinical Research Center for Respiratory Diseases,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health(NCCH),Beijing 100045,China)
出处
《中国防痨杂志》
CAS
2018年第9期917-923,共7页
Chinese Journal of Antituberculosis
关键词
儿童
结核
支气管疾病
支气管镜检查
疾病特征
Child
Tuberculosis
Bronchial diseases
Bronchoscopy
Disease attributes