摘要
目的探讨左旋甲状腺素钠(L-T4)治疗新生儿先天性甲状腺功能减低症(CH)的临床效果。方法选取我院2007年12月至2017年12月确诊为CH的新生儿130例,按照出生顺序分为观察组和对照组各65例。对照组予以小剂量L-T_4治疗,观察组予以大剂量L-T_4治疗。比较两组患儿治疗3个月、 6个月后的体格发育、甲状腺功能情况。结果治疗3个月、 6个月后,两组患儿的身高、头围、 FT_3、 FT_4水平比较差异均无统计学意义(P>0.05)。治疗3个月、 6个月后,观察组的体重、 TSH水平均高于对照组(P <0.05)。结论采用L-T_4治疗CH能够有效改善患儿的临床症状,可取本研究大剂量和小剂量的中间值,并根据患儿实际具体情况进行调整,避免对患儿造成损伤。
Objective To explore the clinical effect of levothyroxine sodium（L-T_4） in the treatment of neonatal congenital hypothyroidism（CH）. Methods 130 cases of newborns diagnosed as CH in our hospital from December 2007 to December 2017 were selected and divided into observation group and control group according to birth order, with 65 cases in each group. The control group was given small dose of L-T_4, while the observation group was given high dose of L-T_4. The physique growth thyroid function 3 months and 6 months after treatment were compared between the two groups. Results 3 months and 6 months after treatment, no statistical difference was found in the height, head circumference, FT_3 and FT_4 levels between the two groups（P 0.05）. 3 months and 6 months after treatment, the body weight and TSH level of the observation group were higher than those of the control group（P 0.05）. Conclusions L-T_4 in the treatment of CH can effectively improve children＇s clinical symptoms. The intermediate value of high dose and small dose in this study can be taken and adjusted according to children＇s actual situation, so as to avoid the injury.
作者
陈丽华
陈志玮
郑少云
黄锶
CHEN Lihua;CHEN Zhiwei;ZHENG Shaoyun;HUANG Si(Zhaoqing Second People ~s Hospital,Zhaoqing 526060,China)
出处
《临床医学工程》
2018年第9期1181-1182,共2页
Clinical Medicine & Engineering
