摘要
宫颈癌是威胁亚洲妇女健康的第二大恶性肿瘤，高危型人乳头瘤病毒（hrHPV）持续感染是其发生的必要条件。近年来，HPV DNA检测越来越多地被应用于宫颈癌初筛。但HPV DNA检测特异度和阳性预测值较低，因此有必要通过HPV阳性人群进行转诊分流，识别真正高风险人群的同时，避免卫生资源的浪费及过度转诊和治疗。细胞学、HPV DNA基因分型、HPV mRNA检测及各种分子生物学标志物检测等分流方法各有利弊。文章旨在对各种分流方法进行简单描述与评价。
Persistently high risk human papillomavirus （HPV） infection is one of the indispensable factors of cervical cancer, which is the secondly most common cancer of women in developing countries. Nowadays HPV DNA detection has been more frequently used in cervical cancer initial screening. However, the specificity and sensitivity of HPV DNA detection are low and the triage of HPV positive women is necessary to identify the authentically high-risk population, and avoid the waste of health care resource and excessive treatment. There are different advantages and disadvantages in triage methods including the cytology, HPV DNA genotype, HPV mRNA detection and biological markers such as p16/Ki-67, respectively. Here we briefly describe and evaluate each triage method.
作者
李菊晓
董丽
李莉
陈汶
Li Juxiao;Dong Li;Li Li;Cheng Wen(Department of epidemiology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China（Li JX,Chen W;Institute of Biomedical Science,Shanxi University,Taiyuan 030006,China（Dong L;Department of Public Health,Xinjiang University,Urumchi 830054,China（Li L)
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2018年第9期641-646,共6页
Chinese Journal of Oncology
