摘要
目的:分析OSAHS患者认知功能与血清神经肽Y(NPY)水平的相关性,探寻评价成人OSAHS患者认知功能状况的生物标志物;对蒙特利尔认知评估量表(MoCA)评价OSAHS患者认知功能的效度进行验证。方法:纳入72例OSAHS患者与16例健康对照者。对受试者进行PSG、MoCA和简易精神状态检查量表测试;ELISA法检测受试者的血清NPY水平。14d后,随机选取对照组中的10例进行MoCA重新测试,检测MoCA的内部一致性、重测信度及同时效度。结果:OSAHS患者认知功能障碍表现在视空间能力、语言及注意力方面,血清NPY水平与MoCA评分呈负相关(r=-0.105),相关性不显著。克朗巴赫系数α检测的MoCA内部一致性是可靠的(0.690),且删去"定向能力"信度增加(0.705);此外,MoCA的重测信度(r=0.884,P=0.001)、同时效度(r=0.701,P<0.01)均是可靠的。结论:MoCA评价成人OSAHS患者认知功能是可靠、稳定、有效的,且删去"定向能力"信度增加;OSAHS患者认知功能障碍表现在视空间能力、语言及注意力方面,随病情加重而明显;血清NPY水平可以反映OSAHS的严重程度;血清NPY水平与MoCA总分呈不显著的负相关,其能否用于评价OSAHS患者认知功能还需进一步验证。
Objective：To analyze the correlation between cognitive function and serum NPY levels in OSAHS patients,and to explore biomarkers for evaluating cognitive function in adult patients with OSAHS.To verify the validity of MoCA in evaluating cognitive function in OSAHS patients.Method：72 patients with OSAHS and 16 healthy controls were included.Subjects were tested for PSG,MoCA,and MMSE;ELISA was used to detect serum NPY levels in subjects.After 14 days,10 patients in the control group were randomly selected for re-testing of MoCA to detect the internal consistency,test-retest reliability and simultaneous validity of MoCA.Result：The cognitive dysfunction of OSAHS patients was manifested in visual spatial ability,language and attention.Serum NPY levels were negatively correlated with MoCA scores（r=-0.105）,and the correlation was not significant.The internal consistency of the MoCA detected by the Cronbach coefficientαis reliable（0.690）,and when ＂directional ability＂ deleted,the reliability increases（0.705）;In addition,both of test-retest reliability（r=0.884,P=0.001）and simultaneous validity（r=0.701,P〈0.01）of MoCA were reliable.Conclusion：MoCA in evaluating the cognitive function of adult with OSAHS is reliable,stable and effective,and when ＂ directional ability＂ deleted,the reliability increases.The cognitive dysfunction of OSAHS patients is manifested in visual spatial ability,language and attention,which is obvious with the disease of severity;serum NPY levels can reflect the severity of OSAHS;there is no significant negative correlation between serum NPY level and MoCA total score.Whether it can be used to evaluate cognitive function in OSAHS patients needs further verification.
作者
唐旋
杨立新
张梅
赵伍西
卢静成
段宗瑾
周宁
颜杰
TANG Xuan;YANG Lixin;ZHANG Mei;ZHAO Wuxi;LUJingcheng;DUAN Zongjin;ZHOUNing;YAN Jie(Department of Otorhinolaryngology,Huainan First People＇s Hospital,H uainan,232000,Chi-na;Department of Neurology,Huainan First People＇s Hospital;Huainan United Universi-ty;Department of Respiratory Medicine,Huainan First People＇s Hospital)
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2018年第18期1414-1417,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
2017年淮南市科技计划项目(No:2017A0591)
