摘要
目的检测N-钙黏蛋白(N-cadherin)、E-钙黏蛋白(E-cadherin)在卵巢浆液性肿瘤中的表达,探讨其在卵巢浆液性肿瘤发生、发展中的作用。方法采用免疫组化SP二步法检测卵巢浆液性腺癌45例、卵巢交界性浆液性腺瘤15例、卵巢浆液性腺瘤15例中N-cadherin、E-cadherin的表达,了解N-cadherin、E-cadherin基因在卵巢浆液性良恶性肿瘤中表达的差异。结果卵巢浆液性腺癌组、卵巢交界性浆液性腺瘤组、卵巢浆液性腺瘤组中N-cadherin阳性表达率分别为62.2%、26.7%、0%,且组织分化程度越低,其阳性表达率越高,差异均有统计学意义(P<0.05);卵巢浆液性腺癌组在不同临床分期中表达差异无统计学意义(P>0.05)。E-cadherin在良性浆液性卵巢肿瘤组中的表达与浆液性卵巢腺癌组和交界性浆液性卵巢腺瘤组相比较,差异均有统计学意义(P<0.05)。N-cadherin、E-cadherin在卵巢浆液性肿瘤中的表达呈负相关性。结论 N-cadherin高表达、Ecadherin低表达与卵巢浆液性腺癌的发生具有相关性。
Objective To detect the expression of N - cadherin and E - cadherin in ovarian serous adenocarcinoma, and to ex- plore its role in the occurrence and transfer process of ovarian Serous adenocarcinoma. Methods The expression of N - cadherin and E -cadher in 15 cases of ovarian serous cystadenoma,and 15 cases of borderline ovarian serous cystadenoma and 45 eases of ovarian se- rous adenocarcinoma （differentiation of low, medium and high differentiation all 15 cases, FIGO stage I - IV ,4 cases were stage I ,8 cases were stage Ⅱ , 14 cases were stage Ⅲ, 19 cases were stage IV ） were examined by immunohistochemical staining （SP）. Results The positive rate for N - cadherin expression in the ovarian serous cystadenoma group, the borderline ovarian serous cystadeno- ma group and the ovarian serous adenocarcinoma groups （differentiation of low, medium and＇ high differentiation） was 62.2% （80% , 73.3% ,33.3% ） ,26.7% ,0% and there were significant different （P 〈0.05） ;The positive expression rate of N -cadherin was higher in the lower level tissue differentiation, but had no obvious difference in different clinical stages （ P 〉 0.05 ）. The expression of E - cad- herin in the borderline ovarian serous cystadenoma group were significantly higher than those in the borderline ovarian serous cystadeno- ma group and the ovarian serous adenocarcinoma groups and there were significant different （ P 〈 0.05 ）. Conclusion N - cadherin is high expression and E - cadherin is low expression in ovarian serous carcinoma. The N - cadherin and E - cadherin may be related to the breeding, infiltration and growth of the ovarian serous glands cancer ceils.
作者
丁永慧
王倩倩
郭华
孙春丽
李烔
DING Yonghui;WANG Qianqian;GUO Hua;SUN Chunli;LI Jiong(Department of gynecology,General Hospital of Ningxia Medical University,Yinchuan 750004,China;Affiliated Hospital of Heze Medical College,Heze 274400,China;Ningxia Medical Uni-versity,Yinchuan 750004,China)
出处
《宁夏医学杂志》
CAS
2018年第8期680-683,I0001,共5页
Ningxia Medical Journal
基金
宁夏自然科学基金资助项目(NZ16134)
宁夏留学人员科技活动项目择优资助项目(2016494)
