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ULK1、p53在大肠癌及癌前病变中的表达及临床意义 被引量:2

Expression and Clinical Significance of ULK1 and p53 in Colorectal Cancer and Precancerous Lesions
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摘要 目的:探讨在大肠癌及癌前病变中ULK1和p53的表达及其临床意义。方法:收集4组不同的组织标本,分别为20例正常黏膜组织、30例大肠腺瘤伴低级别上皮内瘤变组织、30例大肠腺瘤伴高级别上皮内瘤变组织和40例大肠癌组织。采用免疫组化法(Maxvision3)检测上述组织中ULK1和p53表达,分析ULK1和p53的表达与临床病理特征的关系。结果:在正常大肠黏膜组织、低级别上皮内瘤变、高级别上皮内瘤变、大肠癌组织中,ULK1阳性率表达呈升高趋势,各组阳性率表达差异有显著性意义(P<0.05);p53阳性率表达也呈升高趋势,各组阳性率表达差异也均有显著性意义(P<0.05)。大肠癌ULK1、p53表达在分化程度、浸润深度、淋巴结转移、TNM分期中差异均有显著性意义(P<0.05),在肿瘤大小中差异没有显著性意义。结论:临床检测ULK1、p53在大肠癌早期诊断、治疗等方面具有重要的临床应用价值。 Objective: To explore the expression and clinical significance of ULK1 and p53 in colorectal cancer and precancerous lesions. Methods: Four different tissue samples were collected.Immunohistochemical method was used to detect the expression of ULK1 and p53 in 4 groups which were 20 specimens of normal colorectal tissue, 30 specimens of low grade intraepithelial neoplasm, 30 specimens of high grade intraepithelial neoplasm and 40 specimens of colorectal cancer.Analyzed the expression of ULK1 and p53,their relationship with clinicopathological characteristics. Results: The positive expression rate of ULKl and p53 protein was raising in normal colorectal tissue, low grade intraepithelial neoplasm,high grade intraepithelial neoplasm and colorectal cancer and each group had significant different expression in the positive rate( P 〈0.05) .In colorectal cancer,the expression of ULK1 and p53 were associated with degrees of differentiation, the depth of infiltration, lymph node metastasis and TNM stage,the diffrence was statistically significant( P 〈 0.05 ), while were not associated with the size( P 〉0.05). Conclusion: ULK1 and p53 have important clinical application value in early diagnosis and treatment of colorectal cancer.
作者 詹义凤 薛敬玲 汤泉泉 张功学 Zhan Yifeng(School of Basic Medicine,Wuhan University,Wuhan 430071)
出处 《数理医药学杂志》 2018年第10期1430-1433,共4页 Journal of Mathematical Medicine
关键词 大肠癌 ULK1 P53 癌前病变 colorectal cancer ULK1 p53 precancerous lesions
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