摘要
目的:本研究首次选用伊立替康同步放化疗治疗宫颈癌,并随访统计了宫颈癌患者的生存质量,以期为促进宫颈癌患者生活质量的研究及更好地改善宫颈癌患者生活质量的研究奠定基础。方法:选自在2014年10月~2015年9月我院诊治的Ⅱb-Ⅳa期宫颈癌患者120例,将所入选的研究对象按照随机对照法分为3组,即单纯放疗组、顺铂同步放化疗组和伊立替康同步放化疗组,各组40例。单纯放疗组给以宫旁照射、体外盆腔照射及腔内照射治疗方法,顺铂同步放化疗组采用同步放化疗结合顺铂进行治疗,伊立替康同步放化疗组采用同步放化疗结合伊立替康进行治疗。观察三组患者治疗后的肿瘤控制情况、术后并发症发生情况以及健康测量结果。结果:三组患者的脉管癌栓浸润与阴道残端浸润相比无统计学差异(P>0.05);宫旁浸润、淋巴结转移方面两两相比,各组间的差异具有统计学意义(P<0.01),而顺铂同步放化疗组与伊立替康同步放化疗组相比差异无统计学意义(P>0.05)。三组患者间的胃肠道反应、骨髓抑制情况差异无统计学意义(P>0.05)。与单纯放疗组相比,顺铂同步放化疗组、伊立替康同步放化疗组的测量结果,差异具有统计学意义(P<0.01);顺铂同步放化疗组的测量结果与伊立替康同步放化疗组相比,差异无统计学意义(P>0.05)。结论:采用伊立替康同步放化疗治疗宫颈癌降低了宫旁浸润、淋巴结转移,同时还可改善患者的健康指标。
Objective： Through adopting irinotecan and synchronous chemoradiation therapyand following up the survival quality of patients with cervical cancer,this paper is to set the foundation forfurther studies in improving the life quality of patients with cervical cancer. Methods： 120 patients with cervical cancer inⅡb-Ⅳa period from October 2014 to September 2015 were chosen anddivided into three groups according to the randomized controlled method,simple radiotherapy group,cisplatin synchronouschemoradiation group and irinotecan synchronouschemoradiation group,with 40 cases in each group. Simple radiotherapy group were givenparauterine irradiation,pelvic irradiation in vitro and intracavitary irradiation treatment. Cisplatinsynchronous chemoradiotherapy group were treated with synchronous chemoradiotherapy combined with cisplatin. Irinotecan synchronous chemoradiation group were given synchronous chemoradiotherapy combined with irinotecan treatment. Tumor control status,postoperative complications and health measurement results of the three groups were analyzed. Results： There was no statistically significant differences in the infiltration of the vascular carcinoma and the infiltration of the vaginal stump among the three groups （P〉 0. 05）. In terms ofparauterine invasion and lymph node metastasis,the differences between groups were statistically significant （P〈 0. 01）. The differences in gastrointestinal reaction and bone marrow suppression among the three groups were not statistically significant （P〉 0. 05）. Compared with the simple radiotherapy group,the measurement results of cisplatin synchronous chemoradiation group and irinotecan synchronous chemoradiation group were statistically significant （P〈 0. 01）. The results of two synchronous chemoradiotherapy groups had no statistically significant difference （P〉 0. 05）. Conclusions： Irinotecan synchronous chemotherapy for cervical cancer can reduce the risk of uterine infiltration and lymph node metastasis,as well as improv
作者
赵肖丽
周伟慢
王辉
王华
孟丽
ZHAO Xiaoli;ZHOU Weiman;FANG Hui;FANG Hua;MENG Li(Department of Gynecology,Dingzhou People＇s Hospital,Dingzhou 073000,Hebei,China;Department of Oncology,Dingzhou People＇s Hospital,Dingzhou 073000,Hebei,China;Department of Gynecology,The Second Hospital Affiliated to Hebei Medical University,Shijiazhuang 05000,Hebei,China)
出处
《中国性科学》
2018年第7期39-42,共4页
Chinese Journal of Human Sexuality
基金
河北省2016年度医学科学研究重点课题计划项目(20160322)
