摘要
目的探讨宫颈癌CT灌注参数变化对放疗敏感性的评估价值。方法收集2014年2月至2016年7月宫颈癌患者120例,均进行CT灌注扫描并计算相关参数[血流量(BF)、血容量(BV)、表面通透性(PS)和平均通过时间(MTT)];同时给予调强放疗,盆腔照射每次1.8~2.0 Gy,每周5~6次,总照射剂量40~45 Gy。放疗4周后评价疗效。采用Logistic回归模型分析影响放疗敏感性的因素。结果 120例患者均按计划完成放疗,获完全缓解34例,部分缓解46例,稳定20例和进展20例,放疗敏感率为66.7%(80/120)。敏感组年龄、体重指数、肿块直径、病理类型、FIGO分期和分化程度与不敏感组的差异无统计学意义(P>0.05),两组淋巴结转移的差异有统计学意义(P<0.05)。敏感组BF低于不敏感组[(59.22±16.30)ml/(min·100 g)vs.(72.04±12.94)ml/(min·100 g)],而BV[(12.14±2.81)ml/100 g vs.(5.68±1.93)ml/100 g]、PS[(20.56±8.52)ml/(min·100 g)vs.(9.10±1.84)ml/(min·100 g)]与MTT[(11.72±4.48)s vs.(10.34±6.22)s]高于不敏感组,差异均有统计学意义(P<0.05)。Logistic多因素分析显示,BV为影响宫颈癌放疗敏感性的独立因素(P<0.05)。结论宫颈癌CT灌注参数能反映和评估调强放疗的敏感性,BV为影响放疗敏感性的主要因素。
Objective To evaluate the value of CT perfusion parameters on the radiotherapy sensitivity of cervical cancer.Methods From February 2014 to July 2016, 120 patients with cervical cancer were enrolled. All the patients were given CT perfusionscanning to caculate the related parameters including blood flow（BF）, blood volume（BV）, mean transit time （MTT） and permeabilitysurface（PS） and intensity modulated radiation therapy. The pelvic irradiation was 1. 8-2. 0 Gy / f, 5-6 times / week, and the total dosewas 40-45 Gy. The curafive effect was evaluated after 4 weeks of radiotherapy. Factors influencing radiotherapy sensitivity were analyzedby Logistic regression model. Results One hundred and twenty patients were completed the radiotherapy. There were complete remis-sion in 34 patients, partial remission in 46 patients, stable disease in 20 patients and disease progression in 20 patients. The radiotherapy sensitivity was 66. 7%（80 / 120）. Age, body mass index, tumor size, pathological type, FIGO staging and differentiation had nodifference between sensitive group and insensitive group （P〉0. 05）. But lymph node metastasis had difference between the two groups（P〈0. 05）. The value of BF in sensitive group was significantly lower than that of insensitive group[（59. 22±16. 30）ml / （min·100g） vs.（72. 04±12. 94） ml / （min·100 g）], while the values of BV[（12. 14± 2. 81） ml / 100 g vs. （ 5. 68± 1. 93） ml / 100 g], MTT[（11. 72±4. 48）s vs.（10. 34±6. 22）s] and PS[（20. 56±8. 52）ml / （min·100 g） vs.（9. 10±1. 84）ml / （min·100 g）] were significantly higher than those in insensitive group （P〈0. 05）. Logistic regression analysis showed that BV was independent factor influencingradiotherapy sensitivity （P〈0. 05）. Conclusion CT perfusion parameters of cervical cancer can evaluate and reflect radiotherapy sen-sitivity. BV is the main factor influencing radiotherapy sensitivity.
作者
黎钧
邓宏亮
张凯
金汉葵
童三龙
雷鸣峰
袁永群
LI Jun;DENG Hongliang;ZHANG Kai;JIN Hankui;TONG Sanlong;LEI Mingfeng;YUAN Yongqun(Department of Radiology,People＇s Hospital of Tongcheng County,Xianning 437400,China)
出处
《临床肿瘤学杂志》
CAS
北大核心
2018年第8期735-738,共4页
Chinese Clinical Oncology
基金
湖北省卫生和计划生育委员会课题资助项目(WJ2015MB003)
关键词
宫颈癌
CT灌注参数
放射治疗
敏感性
Cervical cancer
CT perfusion parameters
Radiotherapy
Sensitivity
