摘要
目的 探讨多参数磁共振成像(multiparameter magnetic resonance imaging, mpMRI)评估宫颈癌放化疗的效果。方法 选取2021年1—12月在首都医科大学附属北京妇产医院经阴道镜活检确诊宫颈癌219例,根据治疗疗效分为完全缓解组和未完全缓解组。患者治疗前行mpMRI评估,之后行同步放化疗治疗,并于治疗后3个月进行mpMRI复查。采用回顾性研究方法,分析2组患者治疗前后宫颈癌灶的表观扩散系数(apparent diffusion coefficient, ADC)及时间-信号强度曲线(time-signal intensity curve, TIC)的变化。结果 治疗3个月后,219例患者中有176例癌灶完全缓解,43例癌灶未完全缓解。治疗后,完全缓解组的ADC明显高于治疗前[(1.20±0.07)×10^(-3)mm^(2)/s比(0.81±0.08)×10^(-3)mm^(2)/s],也明显高于未完全缓解组[(1.20±0.07)×10^(-3)mm^(2)/s比(0.71±0.09)×10^(-3)mm^(2)/s],差异均有统计学意义(P <0.05);治疗前后,未完全缓解组ADC值无明显变化(P> 0.05)。治疗前,完全缓解组TIC曲线类型以流出型为主(135例),治疗后以流入型为主(163例),差异有统计学意义(χ^(2)=283.500,P <0.001);治疗前,未完全缓解组TIC曲线类型以流出型为主(23例),治疗后以流出型为主(20例),差异无统计学意义(χ^(2)=0.790,P> 0.05)。结论 mpMRI可用于评估宫颈癌放化疗的疗效,ADC值和TIC曲线可作为指导宫颈癌临床治疗的重要依据。
Objective To explore the effect of multi-parametric magnetic resonance imaging(mpMRI)in the efficacy of radiotherapy and chemotherapy for cervical cancer.Methods A total of 219 patients with cervical cancer diagnosed by colposcopy biopsy in Beijing Obstetrics and Gynecology Hospital,Capital Medical University from January to December 2021 were selected,and were divided into complete and incomplete remission group according to the therapeutic effect.All patients were evaluated by mpMRI before treatment,and then underwent radiotherapy and chemotherapy treatment and reexamined by mpMRI.The changes of the apparent diffusion coefficient(ADC)and time-signal intensity curve(TIC)of cervical cancer before and after treatment were retrospective analyzed.Results After three months of treatment,the 176 of 219 patients had complete remission,and 43 patients had incomplete remission.After treatment,the ADC value of the complete remission group was significantly higher than that before treatment[(1.20±0.07)×10^(-3) mm^(2)/s vs.(0.81±0.08)×10^(-3) mm^(2)/s],and it was also significantly higher than that of the incomplete remission group[(1.20±0.07)×10^(-3) mm^(2)/s vs.(0.71±0.09)×10^(-3) mm^(2)/s],and the differences were both statistically significant(P<0.05).The ADC value of cancer before and after treatment had no significant change in the incomplete remission group(P>0.05).Before and after treatment,there was no significant change in ADC value in the incomplete remission group(P>0.05).Before treatment,the type of TIC curve in complete remission group was mainly outflow(135 cases),and inflow after treatment(163 cases),with a statistically significant difference(χ^(2)=283.50,P<0.01).Before treatment,the type of TIC curve in incomplete remission group was mainly outflow(23 cases),and also outflow after treatment(20 cases),and the difference was not statistically significant(χ^(2)=0.790,P>0.05).Conclusions The mpMRI can evaluate the efficacy of radiotherapy and chemotherapy for cervical cancer.The ADC value and TIC cur
作者
刘明明
梁宇霆
王新莲
王克扬
王艳菊
崔悦
刘洋
Liu Mingming;Liang Yuting;Wang Xinlian;Wang Keyang;Wang Yanju;Cui Yue;Liu Yang(Department of Radiology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing Maternal and Child Health Care Hospital,Beijing 100006,China)
出处
《北京医学》
CAS
2023年第2期125-129,共5页
Beijing Medical Journal
关键词
多参数磁共振成像
宫颈癌
表观扩散系数
时间-信号强度曲线
放化疗
multi parameter magnetic resonance imaging(mpMRI)
cervical cancer
apparent diffusion coefficient(ADC)
time-signal intensity curve(TIC)
radiotherapy and chemotherapy
