摘要
微针经近20年的发展,从最初的实心微针,逐渐演变成包括包衣微针、中空微针、可溶性微针及水凝胶微针在内的5大种类。在可递送的药物品种及剂型大幅增加的同时,微针的应用范围也从皮肤拓展到口腔黏膜、胃肠道黏膜、指甲、眼巩膜及阴道黏膜等方面,临床价值与日俱增。本文总结了微针给药原理及各型微针的优缺点,探讨了提高药物递送效率的方法及急需解决的问题,概括了微针技术在经皮肤及其他组织器官给药方面的研究现状,并综述了微针在小分子可溶药物、疫苗及生物大分子给药领域的应用和商业化进展。
Microneedle technique is a breakthrough progress in the field of transdermal drug delivery. In the past two decades, microneedles have gradually evolved into five categories from its initial prototype： solid microneedles, coated microneedles, hollow microneedles, soluble microneedles, and hydrogel microneedles. With the dramatic increasing number of deliverable drugs and dosage forms, the application range of microneedles has also expanded from the skin to the oral mucosa, gastrointestinal mucosa, nails, eye sclera and vaginal mucosa. The clinical value of microneedles has been increasing, but challenges still exist. The present article summarizes the principles of microneedles dosing and the pros and cons of various types of microneedles, discusses measures undertaken to improve the drug delivery efficiency, reviews application expansion of microneedles technique in skin and other organs or tissues for soluble small molecules, vaccines, and biomacromolecules, and provides a general overview about the commercialization of microneedles products and the problems that need to be solved.
作者
巫传玲
WU Chuanling(School of Pharmacy,Chengdu Medical College,Chengdu 610500)
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2018年第9期1221-1229,共9页
Chinese Journal of Pharmaceuticals
关键词
微针
给药途径
递送效率
应用
microneedles
route of administration
delivery efficiency
application
