摘要
目的食管癌是危害中国人群健康的最主要肿瘤之一。研究表明,外周血嗜中性粒细胞-淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)和血小板-淋巴细胞比值(platelet to lymphocyte ratio,PLR)是肿瘤发生、发展的重要炎性生物标志物。本研究探讨治疗前外周血中NLR和PLR与食管鳞癌患者临床病理特征相关性,以期为食管鳞癌早期诊断和预后研究提供线索。方法连续选取2010-12-01-2011-12-30在河南省林州市肿瘤医院经组织病理学确诊的食管鳞癌患者271例作为研究对象。收集患者人口学基本信息和临床病理特征,以及患者治疗/手术前血常规参数检测值。计算NLR和PLR,并按照中位数分组,NLR<2.53为低NLR组(n=138),NLR≥2.53为高NLR组(n=133);PLR<130.4为低PLR组(n=136),PLR≥130.4为高PLR组(n=135)。采用χ2检验或Fisher确切概率法比较分类资料组间差异性,用独立样本Mann-Whitney U检验比较定量资料的组间差异性。结果 271例患者中,Ⅰ~Ⅱ期178例(65.7%),Ⅲ~Ⅳ期患者93例(34.3%)。将NLR按照中位数分组发现,病理分期差异有统计学意义,χ2=7.028,P=0.008;年龄、分化程度、浸润深度、淋巴结转移和远处转移等临床病理特征差异无统计学意义,P>0.05;NLR作为定量数据在病理分期中差异有统计学意义,z=-2.348,P=0.019。将PLR按照中位数分组后,在各临床病理资料中未见明显差异,P>0.05。结论 NLR对食管鳞癌结局有一定预示作用,可为食管鳞癌的早期诊断提供一定线索。
OBJECTIVE Esophageal cancer has been one of the most important cancer against the health of the Chi- nese population. Neutrophil to lymphocyte ratio（NLR） and platelet to lymphocyte ratio（PLR） have been reported to be in- flammatory biomarker for tumor occurrence and development. The objective of this study was to explore the relationship between NLR,PLR and clinic pathological factors,and provide clues for the early diagnosis and prognosis of esophageal squamous cell carcinoma. METHODS We continuously reviewed 271 patients with esophageal carcinoma confirmed by histopathology from December 2010 to December 2011 in Linzhou Tumor Hospital of Henan province. The basic informa- tion,clinic pathological features and the pretreatment or preoperative blood routine characters were collected. The NLR, PLR were calculated and divided into two groups by the median respectively（NLR〈2.53 or NLR≥2.53 ;PLR〈130.4 or PLR≥130.4）. RESULTS For 271 patients there were 178（65.7%） in stage Ⅰ/ Ⅱ ,93（34.3%） in stage Ⅲ/Ⅳ. For NLR there was a statistical significant difference between different TNM stages divided by median （ there was astatistical significant difference between different TNM stages as quantitative data For PLR there was no statistical significant difference in each group. CONCLUSION NLR ：（2 =7. 028,P=0. 008）;also （z=-2. 348,P=0. 019）. may be associated with the outcome of esophageal cancer,may provide clues for the early diagnosis of esophageal squamous cell carcinoma.
作者
郭旭东
马箐
马山蕊
李新庆
丁元杰
于亮
魏文强
刘芬
GUO Xu-dong;MA Qing;MA Sharrrui;LI Xin-qing;DING Yuan-jie;YU Liang;WEI Wen-qiang;LIU Fen(Department of Epidemiology ＆ Statistics,School of Public Health,Capital Medical University,Beijing 100069,P.R.China;Center of Cancer Register Room of Tumor Epidemiology,Tumor Hospital of Peking Union Medical College,Chinese Academy of Medical Science,Beijing 100021,P.R.China;Department of Epidemiology,Tumor Hospital of Linzhou,Linzhou 456500,P.R.China)
出处
《中华肿瘤防治杂志》
CAS
北大核心
2018年第15期1081-1084,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
国家自然科学基金(81473056
81573224)
北京市自然科学基金(7132023)
北京市教委科研计划一般项目(KM201710025006)
